A Pharmacogenomic Landscape in Human Liver Cancers

doi:10.1016/j.ccell.2019.07.001

	A Pharmacogenomic Landscape in Human Liver Cancers
	Qiu, Zhixin 1; Li, Hong 2; Zhang, Zhengtao 1; Zhu, Zhenfeng 3; He, Sheng2,12 ; Wang, Xujun 4; Wang, Pengcheng 5; Qin, Jianjie 6; Zhuang, Liping 3; Wang, Wei 7; Xie, Fubo 7; Gu, Ying 7; Zou, Keke 2; Li, Chao 2; Li, Chun 1; Wang, Chenhua 1; Cen, Jin 1; Chen, Xiaotao 1; Shu, Yajing 1; Zhang, Zhao 1; Sun, Lulu 1; Min, Lihua 1; Fu, Yong 8; Huang, Xiaowu 5; Lv, Hui 4; Zhou, He 7; Ji, Yuan 11; Zhang, Zhigang 9; Meng, Zhiqiang 3; Shi, Xiaolei 10; Zhang, Haibin 8; Li, Yixue 2; Hui, Lijian1,12,13
	2019-08-12
发表期刊	CANCER CELL (IF:48.8[JCR-2023],42.1[5-Year])
ISSN	1535-6108
卷号	36 期号:2 页码:179-+
发表状态	已发表
DOI	10.1016/j.ccell.2019.07.001
摘要	Liver cancers are highly heterogeneous with poor prognosis and drug response. A better understanding between genetic alterations and drug responses would facilitate precision treatment for liver cancers. To characterize the landscape of pharmacogenomic interactions in liver cancers, we developed a protocol to establish human liver cancer cell models at a success rate of around 50% and generated the Liver Cancer Model Repository (LIMORE) with 81 cell models. LIMORE represented genomic and transcriptomic heterogeneity of primary cancers. Interrogation of the pharmacogenomic landscape of LIMORE discovered unexplored gene-drug associations, including synthetic lethalities to prevalent alterations in liver cancers. Moreover, predictive biomarker candidates were suggested for the selection of sorafenib-responding patients. LIMORE provides a rich resource facilitating drug discovery in liver cancers.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Major Science and Technology Projects of China[2018ZX09711002-009]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000480434200008
出版者	CELL PRESS
WOS关键词	HEPATITIS-B-VIRUS ; HEPATOCELLULAR-CARCINOMA ; ORGANOID CULTURES ; CELL-LINES ; MUTATIONAL LANDSCAPE ; LARGE-SCALE ; MODELS ; GENOME ; CATENIN ; SENSITIVITY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/64565
专题	生命科学与技术学院_特聘教授组_惠利健组生命科学与技术学院_博士生
通讯作者	Shi, Xiaolei; Zhang, Haibin; Li, Yixue; Hui, Lijian
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Shanghai Inst Biochem & C, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol,Shanghai Inst, CAS Key Lab Computat Biol,Shanghai Inst Nutr & Hl, Shanghai, Peoples R China 3.Fudan Univ, Collaborat Innovat Ctr Canc Med, Dept Minimally Invas Therapy, Shanghai Canc Ctr,Dept Oncol,Shanghai Med Coll, Shanghai 200032, Peoples R China 4.Shanghai Jiao Tong Univ, SJTU Yale Joint Ctr Biostat, Dept Bioinformat & Biostat, Shanghai 200240, Peoples R China 5.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas, Shanghai 200032, Peoples R China 6.Nanjing Med Univ, Liver Transplantat Ctr, Key Lab Living Donor Liver Transplantat, Minist Publ Hlth,Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China 7.Shanghai ChemPartner Co Ltd, Shanghai 201203, Peoples R China 8.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 5, Shanghai 200438, Peoples R China 9.Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA 10.Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Hepatobiliary Surg, Nanjing 211166, Jiangsu, Peoples R China 11.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China 12.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 13.Chinese Acad Sci, Biores Innovat Ctr Suzhou, Shanghai Inst Biochem & Cell Biol, Suzhou 215121, Jiangsu, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Qiu, Zhixin,Li, Hong,Zhang, Zhengtao,et al. A Pharmacogenomic Landscape in Human Liver Cancers[J]. CANCER CELL,2019,36(2):179-+.
APA	Qiu, Zhixin.,Li, Hong.,Zhang, Zhengtao.,Zhu, Zhenfeng.,He, Sheng.,...&Hui, Lijian.(2019).A Pharmacogenomic Landscape in Human Liver Cancers.CANCER CELL,36(2),179-+.
MLA	Qiu, Zhixin,et al."A Pharmacogenomic Landscape in Human Liver Cancers".CANCER CELL 36.2(2019):179-+.