APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems

doi:10.1016/j.tcb.2019.03.001

	APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems
	Kimata, Yuu1,2
	2019-07
发表期刊	TRENDS IN CELL BIOLOGY (IF:13.0[JCR-2023],19.5[5-Year])
ISSN	0962-8924
卷号	29 期号:7 页码:591-603
发表状态	已发表
DOI	10.1016/j.tcb.2019.03.001
摘要	The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. I describe how APC/C regulates distinct processes during the course of differentiation by deploying diverse molecular machineries in a variety of developmental contexts. Also, I discuss the significance and clinical relevance of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular processes with cell proliferation control.
收录类别	SCI ; SCIE
语种	英语
资助项目	Cancer Research UK[CRUK-A12874]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000471247900007
出版者	ELSEVIER SCIENCE LONDON
WOS关键词	ANAPHASE-PROMOTING COMPLEX ; SISTER-CHROMATID SEPARATION ; DEVELOPING DROSOPHILA EYE ; EARLY MITOTIC DEGRADATION ; APC/C-FZR/CDH1-DEPENDENT REGULATION ; CENTROSOME DUPLICATION ; PROTEIN STABILIZATION ; MORPHOGENETIC FURROW ; TRANSCRIPTION FACTOR ; CYCLE PROGRESSION
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/49002
专题	生命科学与技术学院_PI研究组_Yuu Kimita组
通讯作者	Kimata, Yuu
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Univ Cambridge, Cambridge, England
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Kimata, Yuu. APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems[J]. TRENDS IN CELL BIOLOGY,2019,29(7):591-603.
APA	Kimata, Yuu.(2019).APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems.TRENDS IN CELL BIOLOGY,29(7),591-603.
MLA	Kimata, Yuu."APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 phase in Multicellular Systems".TRENDS IN CELL BIOLOGY 29.7(2019):591-603.