Muller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors

doi:10.1016/j.celrep.2019.05.011

	Muller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors
	Zhang, Rong-wei 1; Du, Wen-jie 1; Prober, David A.4; Du, Jiu-lin1,2,3
	2019-06-04
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	27 期号:10 页码:2871-+
发表状态	已发表
DOI	10.1016/j.celrep.2019.05.011
摘要	Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavior and function of glia in retinal waves remain unclear. Using multiple in vivo methods in larval zebrafish, we found that Muller glial cells (MGCs) display wave-like spontaneous activities, which start at MGC processes within the inner plexiform layer, vertically spread to their somata and endfeet, and horizontally propagate into neighboring MGCs. MGC waves depend on glutamatergic signaling derived from bipolar cells. Moreover, MGCs express both glia-specific glutamate transporters and the AMPA subtype of glutamate receptors. The AMPA receptors mediate MGC calcium activities during retinal waves, whereas the glutamate transporters modulate the occurrence of retinal waves. Thus, MGCs can sense and regulate retinal waves via AMPA receptors and glutamate transporters, respectively.
收录类别	SCI ; SCIE
语种	英语
资助项目	Shanghai Municipal Science and Technology Major Project[18JC1410100] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000470098200008
出版者	CELL PRESS
WOS关键词	NEURONAL-ACTIVITY ; ZEBRAFISH RETINA ; EXCITATION ; SYNAPSES ; GLAST
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/48991
专题	生命科学与技术学院_特聘教授组_杜久林组
通讯作者	Zhang, Rong-wei; Du, Jiu-lin
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Sch Future Technol, 19A Yu Quan Rd, Beijing 100049, Peoples R China 4.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Rong-wei,Du, Wen-jie,Prober, David A.,et al. Muller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors[J]. CELL REPORTS,2019,27(10):2871-+.
APA	Zhang, Rong-wei,Du, Wen-jie,Prober, David A.,&Du, Jiu-lin.(2019).Muller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.CELL REPORTS,27(10),2871-+.
MLA	Zhang, Rong-wei,et al."Muller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors".CELL REPORTS 27.10(2019):2871-+.