消息
×
loading..
Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes
2024-10-30
发表期刊NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN2041-1723
卷号15期号:1
发表状态已发表
DOI10.1038/s41467-024-53728-x
摘要["The selective incorporation of a deuterium atom into small molecules with high selectivity is highly valuable for medical and chemical research. Unfortunately, this remains challenging due to the complete deuteration caused by commonly used hydrogen isotope exchange strategies. We report the development of a photocatalytic selective monodeuteration protocol utilizing C-C bond as the unconventional functional handle. The synergistic combination of radical-mediated C-C bond scission and deuterium atom transfer processes enables the effective constructions of benzylic CDH moieties with high selectivity for monodeuteration. The combinational use of a bisphosphonium photocatalyst, thiol catalyst, and CH3OD deuteration agent provides operationally simple conditions for photocatalytic monodeuteration. Moreover, the photoinduced electron transfer process of the bisphosphonium photocatalyst is elucidated through a series of spectroscopy experiments, identifying a peculiar back electron transfer process that can be regulated by subsequent nucleophilic additions.","Incorporation of deuterium into small molecules in the place of hydrogens can alter the properties of the molecule in ways that provide benefits without affecting the core function of the molecule. Here, the authors report a ring-opening deuteration of cyclic alkanes via biphosphonium photocatalysis."]
URL查看原文
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China (National Science Foundation of China)[2021YFA1500100] ; National Key R&D Program of China["22125111","21971163"] ; National Natural Science Foundation of China[21XD1424600] ; Natural Science Foundation of Shanghai[XDB0610000]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:001346144300001
出版者NATURE PORTFOLIO
引用统计
正在获取...
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/483950
专题物质科学与技术学院
物质科学与技术学院_PI研究组_刘伟民组
通讯作者Yang, Yi; Liu, Weimin; Zuo, Zhiwei
作者单位
1.Sichuan Univ Sci & Engn, Sichuan Inst Higher Educ, Innovat Ctr Chenguang High Performance Fluorine Ma, Key Lab Green Chem, Zigong 643000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Xu, Yuanli,Chen, Wenlong,Pu, Ruihua,et al. Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes[J]. NATURE COMMUNICATIONS,2024,15(1).
APA Xu, Yuanli.,Chen, Wenlong.,Pu, Ruihua.,Ding, Jia.,An, Qing.,...&Zuo, Zhiwei.(2024).Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes.NATURE COMMUNICATIONS,15(1).
MLA Xu, Yuanli,et al."Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes".NATURE COMMUNICATIONS 15.1(2024).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Xu, Yuanli]的文章
[Chen, Wenlong]的文章
[Pu, Ruihua]的文章
百度学术
百度学术中相似的文章
[Xu, Yuanli]的文章
[Chen, Wenlong]的文章
[Pu, Ruihua]的文章
必应学术
必应学术中相似的文章
[Xu, Yuanli]的文章
[Chen, Wenlong]的文章
[Pu, Ruihua]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1038@s41467-024-53728-x.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。