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ShanghaiTech University Knowledge Management System
Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes | |
2024-10-30 | |
发表期刊 | NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year]) |
EISSN | 2041-1723 |
卷号 | 15期号:1 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-024-53728-x |
摘要 | ["The selective incorporation of a deuterium atom into small molecules with high selectivity is highly valuable for medical and chemical research. Unfortunately, this remains challenging due to the complete deuteration caused by commonly used hydrogen isotope exchange strategies. We report the development of a photocatalytic selective monodeuteration protocol utilizing C-C bond as the unconventional functional handle. The synergistic combination of radical-mediated C-C bond scission and deuterium atom transfer processes enables the effective constructions of benzylic CDH moieties with high selectivity for monodeuteration. The combinational use of a bisphosphonium photocatalyst, thiol catalyst, and CH3OD deuteration agent provides operationally simple conditions for photocatalytic monodeuteration. Moreover, the photoinduced electron transfer process of the bisphosphonium photocatalyst is elucidated through a series of spectroscopy experiments, identifying a peculiar back electron transfer process that can be regulated by subsequent nucleophilic additions.","Incorporation of deuterium into small molecules in the place of hydrogens can alter the properties of the molecule in ways that provide benefits without affecting the core function of the molecule. Here, the authors report a ring-opening deuteration of cyclic alkanes via biphosphonium photocatalysis."] |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China (National Science Foundation of China)[2021YFA1500100] ; National Key R&D Program of China["22125111","21971163"] ; National Natural Science Foundation of China[21XD1424600] ; Natural Science Foundation of Shanghai[XDB0610000] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001346144300001 |
出版者 | NATURE PORTFOLIO |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/483950 |
专题 | 物质科学与技术学院 物质科学与技术学院_PI研究组_刘伟民组 |
通讯作者 | Yang, Yi; Liu, Weimin; Zuo, Zhiwei |
作者单位 | 1.Sichuan Univ Sci & Engn, Sichuan Inst Higher Educ, Innovat Ctr Chenguang High Performance Fluorine Ma, Key Lab Green Chem, Zigong 643000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
通讯作者单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Xu, Yuanli,Chen, Wenlong,Pu, Ruihua,et al. Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes[J]. NATURE COMMUNICATIONS,2024,15(1). |
APA | Xu, Yuanli.,Chen, Wenlong.,Pu, Ruihua.,Ding, Jia.,An, Qing.,...&Zuo, Zhiwei.(2024).Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes.NATURE COMMUNICATIONS,15(1). |
MLA | Xu, Yuanli,et al."Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes".NATURE COMMUNICATIONS 15.1(2024). |
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