上海科技大学知识管理系统

Background: Prolonged confinement in enclosed environments has raised concerns about its effects on both physical and mental health. Although increased rates of depression or anxiety during COVID-19 lockdowns have been reported, the effects of short-term restrictions on social activities and physical on brain function and structure remain poorly known. Methods: This study explored longitudinal changes in brain gray matter volume (GMV) and functional connectivity (FC) immediately after and four months following a short-term lockdown in comparison to pre-lockdown conditions. MRI data were collected from 20 participants before the lockdown, from 29 participants (14 original, 15 new) two months post-lockdown, and from 27 out of the 29 participants four months post-lifting of the lockdown. Results: Results showed significant GMV reductions in the right gyrus rectus and cuneus post-lockdown, with further reductions observed four months after lifting the restrictions, affecting additional brain regions. Longitudinal FC trajectories revealed decreased connectivity between the default mode network (DMN) and sensorimotor/attention networks post-lockdown, and recovery after four months post-lifting of the lockdown. Conclusions: The observed plasticity in brain FC indicates substantial recovery potential with the potential long-term effect of structural changes. Our findings offer insights into the effects of isolation on the human brain, potentially informing rehabilitation mechanisms and interventions for individuals in similar conditions.