Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease
2024-11-28
发表期刊FRONTIERS IN AGING NEUROSCIENCE (IF:4.1[JCR-2023],4.6[5-Year])
ISSN1663-4365
卷号16
发表状态已发表
DOI10.3389/fnagi.2024.1465181
摘要

Objectives To investigate the potential trade-offs among brain structural network characteristics across different stages of cognitive impairment in cerebral small vessel disease (CSVD) based on diffusion tensor imaging (DTI).Methods A total of 264 CSVD patients, including 95 patients with non-cognitive impairment (NCI), 142 with mild cognitive impairment (MCI), 27 with vascular dementia (VaD), and 30 healthy controls (HC) underwent cognitive test and brain diffusion magnetic resonance imaging (MRI). The brain structural network was constructed using connections between 90 cortical and subcortical regions. Network characteristics, including sparsity, redundancy, global efficiency (Eg), and local efficiency (Eloc), were calculated.Results Sparsity and redundancy significantly declined in the NCI group compared to the HC group. Eg was significantly reduced in the MCI group compared to the NCI group. All network characteristics declined in the VaD group compared to the MCI group. In the NCI group, both sparsity and redundancy were significantly positively correlated with Montreal Cognitive Assessment (MoCA). In the MCI group, there was significant positive correlation between Eg and MoCA. In the VaD group, there was significant negative correlation between Eloc and MoCA. When controlling for sparsity, Eloc exhibited a significant negative correlation with Eg in all three CSVD groups, while redundancy displayed a significant negative correlation with Eg specifically in MCI group.Conclusion Our study provides evidence for the heterogeneous alterations in brain structural network across different stages of cognitive impairment in CSVD. The disconnection of brain structural network at NCI stage is mainly the loss of redundant connections. The decline of Eg is the vital factor for cognitive impairment at MCI stage. The decline of all network characteristics is the prominent manifestation at VaD stage. Throughout the cognitive decline process in CSVD, there are trade-offs among the brain network wiring cost, integration, and segregation.

关键词cerebral small vessel disease cognitive impairment diffusion tensor imaging network efficiency brain reserve
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收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:001374834200001
出版者FRONTIERS MEDIA SA
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/461490
专题生物医学工程学院
生物医学工程学院_PI研究组_沈定刚组
通讯作者Shen, Dinggang; Zhou, Yan
作者单位
1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Radiol, Shanghai, Peoples R China
2.Shanghai Artificial Intelligence Lab, Shanghai, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China
4.ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China
通讯作者单位生物医学工程学院
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GB/T 7714
Wang, Yao,Liu, Mianxin,Chen, Yuewei,et al. Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2024,16.
APA Wang, Yao.,Liu, Mianxin.,Chen, Yuewei.,Qiu, Yage.,Han, Xu.,...&Zhou, Yan.(2024).Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease.FRONTIERS IN AGING NEUROSCIENCE,16.
MLA Wang, Yao,et al."Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease".FRONTIERS IN AGING NEUROSCIENCE 16(2024).
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