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Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease | |
2024-11-28 | |
发表期刊 | FRONTIERS IN AGING NEUROSCIENCE (IF:4.1[JCR-2023],4.6[5-Year]) |
ISSN | 1663-4365 |
卷号 | 16 |
发表状态 | 已发表 |
DOI | 10.3389/fnagi.2024.1465181 |
摘要 | Objectives To investigate the potential trade-offs among brain structural network characteristics across different stages of cognitive impairment in cerebral small vessel disease (CSVD) based on diffusion tensor imaging (DTI).Methods A total of 264 CSVD patients, including 95 patients with non-cognitive impairment (NCI), 142 with mild cognitive impairment (MCI), 27 with vascular dementia (VaD), and 30 healthy controls (HC) underwent cognitive test and brain diffusion magnetic resonance imaging (MRI). The brain structural network was constructed using connections between 90 cortical and subcortical regions. Network characteristics, including sparsity, redundancy, global efficiency (Eg), and local efficiency (Eloc), were calculated.Results Sparsity and redundancy significantly declined in the NCI group compared to the HC group. Eg was significantly reduced in the MCI group compared to the NCI group. All network characteristics declined in the VaD group compared to the MCI group. In the NCI group, both sparsity and redundancy were significantly positively correlated with Montreal Cognitive Assessment (MoCA). In the MCI group, there was significant positive correlation between Eg and MoCA. In the VaD group, there was significant negative correlation between Eloc and MoCA. When controlling for sparsity, Eloc exhibited a significant negative correlation with Eg in all three CSVD groups, while redundancy displayed a significant negative correlation with Eg specifically in MCI group.Conclusion Our study provides evidence for the heterogeneous alterations in brain structural network across different stages of cognitive impairment in CSVD. The disconnection of brain structural network at NCI stage is mainly the loss of redundant connections. The decline of Eg is the vital factor for cognitive impairment at MCI stage. The decline of all network characteristics is the prominent manifestation at VaD stage. Throughout the cognitive decline process in CSVD, there are trade-offs among the brain network wiring cost, integration, and segregation. |
关键词 | cerebral small vessel disease cognitive impairment diffusion tensor imaging network efficiency brain reserve |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[ |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
WOS类目 | Geriatrics & Gerontology ; Neurosciences |
WOS记录号 | WOS:001374834200001 |
出版者 | FRONTIERS MEDIA SA |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/461490 |
专题 | 生物医学工程学院 生物医学工程学院_PI研究组_沈定刚组 |
通讯作者 | Shen, Dinggang; Zhou, Yan |
作者单位 | 1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Radiol, Shanghai, Peoples R China 2.Shanghai Artificial Intelligence Lab, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China 4.ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China |
通讯作者单位 | 生物医学工程学院 |
推荐引用方式 GB/T 7714 | Wang, Yao,Liu, Mianxin,Chen, Yuewei,et al. Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2024,16. |
APA | Wang, Yao.,Liu, Mianxin.,Chen, Yuewei.,Qiu, Yage.,Han, Xu.,...&Zhou, Yan.(2024).Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease.FRONTIERS IN AGING NEUROSCIENCE,16. |
MLA | Wang, Yao,et al."Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease".FRONTIERS IN AGING NEUROSCIENCE 16(2024). |
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