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Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products
2018-06
发表期刊ARCHIVAL SCIENCE (IF:1.4[JCR-2023],1.8[5-Year])
ISSN1389-0166
卷号3期号:2页码:83-89
发表状态已发表
DOI10.1016/j.synbio.2018.02.002
摘要Natural products with significant biological activities continuously act as rich sources for drug discovery and development. To harness the potential of these valuable compounds, robust methods need to be developed for their rapid and sustainable production. Cell-free biosynthesis of pharmaceutical natural products by in vitro reconstruction of the entire biosynthetic pathways represents one such solution. In this review, we focus on in vitro biosynthesis of two important classes of natural products, polyketides (PKs) and nonribosomal peptides (NRPs). First, we summarize purified enzyme-based systems for the biosynthesis of PKs, NRPs, and PK/NRP hybrids. Then, we introduce the cell-free protein synthesis (CFPS)-based technology for natural product production. With that, we discuss challenges and opportunities of cell-free synthetic biology for in vitro biosynthesis of natural products. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co.
关键词Cell-free synthetic biology Purified enzymes Cell-free protein synthesis Polyketides Nonribosomal peptides In vitro biosynthesis Natural products
收录类别ESCI ; SCIE
语种英语
WOS研究方向Biotechnology & Applied Microbiology
WOS类目Biotechnology & Applied Microbiology
WOS记录号WOS:000441188400002
出版者KEAI PUBLISHING LTD
WOS关键词FREE PROTEIN-SYNTHESIS ; PEPTIDYL NUCLEOSIDE ANTIBIOTICS ; ESCHERICHIA-COLI ; ASSEMBLY-LINE ; HETEROLOGOUS EXPRESSION ; PACIDAMYCIN GROUP ; YERSINIA-PESTIS ; CHEMICAL LOGIC ; FREE PLATFORM ; POLYKETIDE
原始文献类型Review
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/45764
专题物质科学与技术学院_PI研究组_李健组
物质科学与技术学院_硕士生
通讯作者Li, Jian
作者单位
ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
第一作者的第一单位物质科学与技术学院
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GB/T 7714
Li, Jian,Zhang, Lingkai,Liu, Wanqiu. Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products[J]. ARCHIVAL SCIENCE,2018,3(2):83-89.
APA Li, Jian,Zhang, Lingkai,&Liu, Wanqiu.(2018).Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products.ARCHIVAL SCIENCE,3(2),83-89.
MLA Li, Jian,et al."Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products".ARCHIVAL SCIENCE 3.2(2018):83-89.
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