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ShanghaiTech University Knowledge Management System
Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products | |
2018-06 | |
发表期刊 | ARCHIVAL SCIENCE (IF:1.4[JCR-2023],1.8[5-Year]) |
ISSN | 1389-0166 |
卷号 | 3期号:2页码:83-89 |
发表状态 | 已发表 |
DOI | 10.1016/j.synbio.2018.02.002 |
摘要 | Natural products with significant biological activities continuously act as rich sources for drug discovery and development. To harness the potential of these valuable compounds, robust methods need to be developed for their rapid and sustainable production. Cell-free biosynthesis of pharmaceutical natural products by in vitro reconstruction of the entire biosynthetic pathways represents one such solution. In this review, we focus on in vitro biosynthesis of two important classes of natural products, polyketides (PKs) and nonribosomal peptides (NRPs). First, we summarize purified enzyme-based systems for the biosynthesis of PKs, NRPs, and PK/NRP hybrids. Then, we introduce the cell-free protein synthesis (CFPS)-based technology for natural product production. With that, we discuss challenges and opportunities of cell-free synthetic biology for in vitro biosynthesis of natural products. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co. |
关键词 | Cell-free synthetic biology Purified enzymes Cell-free protein synthesis Polyketides Nonribosomal peptides In vitro biosynthesis Natural products |
收录类别 | ESCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Biotechnology & Applied Microbiology |
WOS类目 | Biotechnology & Applied Microbiology |
WOS记录号 | WOS:000441188400002 |
出版者 | KEAI PUBLISHING LTD |
WOS关键词 | FREE PROTEIN-SYNTHESIS ; PEPTIDYL NUCLEOSIDE ANTIBIOTICS ; ESCHERICHIA-COLI ; ASSEMBLY-LINE ; HETEROLOGOUS EXPRESSION ; PACIDAMYCIN GROUP ; YERSINIA-PESTIS ; CHEMICAL LOGIC ; FREE PLATFORM ; POLYKETIDE |
原始文献类型 | Review |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/45764 |
专题 | 物质科学与技术学院_PI研究组_李健组 物质科学与技术学院_硕士生 |
通讯作者 | Li, Jian |
作者单位 | ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
第一作者的第一单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Li, Jian,Zhang, Lingkai,Liu, Wanqiu. Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products[J]. ARCHIVAL SCIENCE,2018,3(2):83-89. |
APA | Li, Jian,Zhang, Lingkai,&Liu, Wanqiu.(2018).Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products.ARCHIVAL SCIENCE,3(2),83-89. |
MLA | Li, Jian,et al."Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products".ARCHIVAL SCIENCE 3.2(2018):83-89. |
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