Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF

doi:10.1016/j.celrep.2017.07.056

	Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF
	Xia, Min 1; Chen, Kun1,2 ; Yao, Xiao 1; Xu, Yichi 3; Yao, Jiaying 3; Yan, Jun 3; Shao, Zhen 3; Wang, Gang1,2
	2017-08-22
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2211-1247
卷号	20 期号:8 页码:1794-1804
发表状态	已发表
DOI	10.1016/j.celrep.2017.07.056
摘要	DNA repair is related to many physiological and pathological processes, including pigmentation. Little is known about the role of the transcriptional cofactor Mediator complex in DNA repair and pigmentation. Here, we demonstrate that Mediator MED23 plays an important role in coupling UV-induced DNA repair to pigmentation. The loss of Med23 specifically impairs the pigmentation process in melanocyte-lineage cells and in zebrafish. Med23 deficiency leads to enhanced nucleotide excision repair (NER) and less DNA damage following UV radiation because of the enhanced expression and recruitment of NER factors to chromatin for genomic stability. Integrative analyses of melanoma cells reveal that MED23 controls the expression of a melanocyte master regulator, Mitf, by modulating its distal enhancer activity, leading to opposing effects on pigmentation and DNA repair. Collectively, the Mediator MED23/MITF axis connects DNA repair to pigmentation, thus providing molecular insights into the DNA damage response and skin-related diseases.
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2017YFA0102701] ; Ministry of Science and Technology of China[2014CB964702]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000408154300006
出版者	CELL PRESS
WOS关键词	EMBRYONIC STEM-CELLS ; XERODERMA-PIGMENTOSUM ; COACTIVATOR COMPLEX ; EXCISION-REPAIR ; MELANOMA ; SUBUNIT ; DIFFERENTIATION ; MELANOCYTES ; DAMAGE ; MELANOGENESIS
原始文献类型	Article
通讯作者	Wang, Gang
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4517
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_王纲组生命科学与技术学院_硕士生
通讯作者	Wang, Gang
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xia, Min,Chen, Kun,Yao, Xiao,et al. Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF[J]. CELL REPORTS,2017,20(8):1794-1804.
APA	Xia, Min.,Chen, Kun.,Yao, Xiao.,Xu, Yichi.,Yao, Jiaying.,...&Wang, Gang.(2017).Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.CELL REPORTS,20(8),1794-1804.
MLA	Xia, Min,et al."Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF".CELL REPORTS 20.8(2017):1794-1804.