Tumor-selective catalytic nanomedicine by nanocatalyst delivery

doi:10.1038/s41467-017-00424-8

	Tumor-selective catalytic nanomedicine by nanocatalyst delivery
	Huo, Minfeng 1,2; Wang, Liying1,2,3 ; Chen, Yu 1; Shi, Jianlin 1
	2017-08-25
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	8
发表状态	已发表
DOI	10.1038/s41467-017-00424-8
摘要	Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst. GOD in sequential nanocatalyst could effectively deplete glucose in tumor cells, and meanwhile produce a considerable amount of H2O2 for subsequent Fenton-like reaction catalyzed by Fe3O4 nanoparticles in response to mild acidic tumor microenvironment. Highly toxic hydroxyl radicals are generated through these sequential catalytic reactions to trigger the apoptosis and death of tumor cells. The current work manifests a proof of concept of catalytic nanomedicine by approaching selectivity and efficiency concurrently for tumor therapeutics.
收录类别	SCI
语种	英语
资助项目	Youth Innovation Promotion Association[2013169]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000408376900005
出版者	NATURE PUBLISHING GROUP
WOS关键词	IRON-OXIDE NANOPARTICLES ; IN-VIVO ; LACTATE-DEHYDROGENASE ; GLUCOSE-METABOLISM ; CANCER-CELLS ; THERAPY ; MICROENVIRONMENTS ; RADIOTHERAPY ; PROGRESSION ; NANOSHEETS
原始文献类型	Article
通讯作者	Chen, Yu ; Shi, Jianlin
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4512
专题	物质科学与技术学院物质科学与技术学院_博士生
通讯作者	Chen, Yu; Shi, Jianlin
作者单位	1.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Huo, Minfeng,Wang, Liying,Chen, Yu,et al. Tumor-selective catalytic nanomedicine by nanocatalyst delivery[J]. NATURE COMMUNICATIONS,2017,8.
APA	Huo, Minfeng,Wang, Liying,Chen, Yu,&Shi, Jianlin.(2017).Tumor-selective catalytic nanomedicine by nanocatalyst delivery.NATURE COMMUNICATIONS,8.
MLA	Huo, Minfeng,et al."Tumor-selective catalytic nanomedicine by nanocatalyst delivery".NATURE COMMUNICATIONS 8(2017).