Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating
Delgado-Pinar, Martina1; Shi, Qing2; Poveda-Wong, Luis1; Delgado-Pinar, Estefania3; Xu, Baojian2; Zhao, Jianlog2; Luis Cruz, Jose1; Andres, Miguel V.1

Nanometric narrowband long period gratings (LPGs) are investigated for the implementation of improved fiber optic biosensors. The reduction of more than one order of magnitude in the linewidth of the LPG with respect to standard LPG at 1500 nm leads to the improvement of the resolution of the sensor. By selecting the proper fabrication parameters (high numerical aperture, relatively high order mode, and large length), LPGs with a 3-dB bandwidth of 1.5 nm were fabricated. The sensitivity of the LPG as a refractometer was calculated and experimentally characterized in detail. In particular, the LP0,17 and LP0,18 resonances were investigated in order to select the most suitable one for the bioexperiments. The surface of the LPG was functionalized and the detection of the hybridization of DNA is demonstrated. When the biosensor was immersed in a 2 mu M solution of the complementary DNA strand, the resonances of the LPG shifted in wavelength. When measuring the response of the sensor in terms of variation of its transmittance as the resonance shifted in wavelength, the sensitivity was similar to 10%/mu M for both resonances. The detection limit was estimated in 10 nM.

KeywordFiber Optics Fiber Optics Sensors Fiber Gratings Biosensors
Indexed BySCI ; EI
Funding ProjectUniversitat de Valencia[UV-INV-AE16-485280]
WOS Research AreaEngineering ; Instruments & Instrumentation ; Physics
WOS SubjectEngineering, Electrical & Electronic ; Instruments & Instrumentation ; Physics, Applied
WOS IDWOS:000407475200016
EI Accession Number20172903946738
EI KeywordsBandwidth ; Biosensors ; Couplings ; Fiber optic sensors ; Fiber optics ; Oligonucleotides ; Optical fiber fabrication ; Optical fibers ; Refractive index ; Resonance ; Sensitivity analysis
Original Document TypeJournals
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorDelgado-Pinar, Martina
Affiliation1.Univ Valencia, Dept Fis Aplicada & Electromagnetismo ICMUV, E-46100 Valencia, Spain
2.Shanghai Tech Univ, Univ Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
3.Univ Valencia, ICMOL, C Catedrat Jose Beltran 2, Paterna 46980, Spain
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GB/T 7714
Delgado-Pinar, Martina,Shi, Qing,Poveda-Wong, Luis,et al. Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating[J]. IEEE SENSORS JOURNAL,2017,17(17):5503-5509.
APA Delgado-Pinar, Martina.,Shi, Qing.,Poveda-Wong, Luis.,Delgado-Pinar, Estefania.,Xu, Baojian.,...&Andres, Miguel V..(2017).Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating.IEEE SENSORS JOURNAL,17(17),5503-5509.
MLA Delgado-Pinar, Martina,et al."Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating".IEEE SENSORS JOURNAL 17.17(2017):5503-5509.
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