Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating
Delgado-Pinar, Martina1; Shi, Qing2; Poveda-Wong, Luis1; Delgado-Pinar, Estefania3; Xu, Baojian2; Zhao, Jianlog2; Luis Cruz, Jose1; Andres, Miguel V.1
2017-09
Source PublicationIEEE SENSORS JOURNAL
ISSN1530-437X
EISSN1558-1748
Volume17Issue:17Pages:5503-5509
Status已发表
DOI10.1109/JSEN.2017.2723759
Abstract

Nanometric narrowband long period gratings (LPGs) are investigated for the implementation of improved fiber optic biosensors. The reduction of more than one order of magnitude in the linewidth of the LPG with respect to standard LPG at 1500 nm leads to the improvement of the resolution of the sensor. By selecting the proper fabrication parameters (high numerical aperture, relatively high order mode, and large length), LPGs with a 3-dB bandwidth of 1.5 nm were fabricated. The sensitivity of the LPG as a refractometer was calculated and experimentally characterized in detail. In particular, the LP0,17 and LP0,18 resonances were investigated in order to select the most suitable one for the bioexperiments. The surface of the LPG was functionalized and the detection of the hybridization of DNA is demonstrated. When the biosensor was immersed in a 2 mu M solution of the complementary DNA strand, the resonances of the LPG shifted in wavelength. When measuring the response of the sensor in terms of variation of its transmittance as the resonance shifted in wavelength, the sensitivity was similar to 10%/mu M for both resonances. The detection limit was estimated in 10 nM.

KeywordFiber Optics Fiber Optics Sensors Fiber Gratings Biosensors
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Indexed BySCI ; EI
Language英语
Funding ProjectUniversitat de Valencia[UV-INV-AE16-485280]
WOS Research AreaEngineering ; Instruments & Instrumentation ; Physics
WOS SubjectEngineering, Electrical & Electronic ; Instruments & Instrumentation ; Physics, Applied
WOS IDWOS:000407475200016
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
EI Accession Number20172903946738
EI KeywordsBandwidth ; Biosensors ; Couplings ; Fiber optic sensors ; Fiber optics ; Oligonucleotides ; Optical fiber fabrication ; Optical fibers ; Refractive index ; Resonance ; Sensitivity analysis
WOS KeywordCHEMICAL SENSORS ; INDEX
Original Document TypeJournals
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4508
Collection信息科学与技术学院
信息科学与技术学院_博士生
Corresponding AuthorDelgado-Pinar, Martina
Affiliation1.Univ Valencia, Dept Fis Aplicada & Electromagnetismo ICMUV, E-46100 Valencia, Spain
2.Shanghai Tech Univ, Univ Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China
3.Univ Valencia, ICMOL, C Catedrat Jose Beltran 2, Paterna 46980, Spain
Recommended Citation
GB/T 7714
Delgado-Pinar, Martina,Shi, Qing,Poveda-Wong, Luis,et al. Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating[J]. IEEE SENSORS JOURNAL,2017,17(17):5503-5509.
APA Delgado-Pinar, Martina.,Shi, Qing.,Poveda-Wong, Luis.,Delgado-Pinar, Estefania.,Xu, Baojian.,...&Andres, Miguel V..(2017).Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating.IEEE SENSORS JOURNAL,17(17),5503-5509.
MLA Delgado-Pinar, Martina,et al."Oligonucleotide-Hybridization Fiber-Optic Biosensor Using a Narrow Bandwidth Long Period Grating".IEEE SENSORS JOURNAL 17.17(2017):5503-5509.
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