ShanghaiTech University Knowledge Management System
| FSO2N3-Mediated On-DNA Diazo-Transfer Chemistry | |
| 2024-08-01 | |
| 发表期刊 | ACS MEDICINAL CHEMISTRY LETTERS (IF:3.5[JCR-2023],3.9[5-Year]) |
| ISSN | 1948-5875 |
| 卷号 | 15期号:9 |
| 发表状态 | 已发表 |
| DOI | 10.1021/acsmedchemlett.4c00307 |
| 摘要 | DNA-encoded library (DEL) is a powerful hit selection technique in both basic science and innovative drug discovery. In this study, we report a robust and straightforward DNA-compatible diazo-transfer reaction utilizing FSO2N3 as the diazo-transfer reagent in solution. This reaction demonstrates high conversions and facile operation while being metal-free and maintaining high levels of DNA fidelity. It is also compatible with a wide range of substrates, allowing for convenient access to both aliphatic and aromatic amines. Consequently, it will further enrich the DEL chemistry toolbox. |
| 关键词 | DNA-encoded chemical library diazo-transfer drug discovery FSO2N3 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[ |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:001298177100001 |
| 出版者 | AMER CHEMICAL SOC |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/421331 |
| 专题 | 免疫化学研究所 免疫化学研究所_特聘教授组_抗体设计学实验室 生命科学与技术学院_博士生 |
| 通讯作者 | Ma, Peixiang; Xu, Hongtao; Zhang, Shuning |
| 作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai 201210, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthoped Implants, Dept Orthoped,Sch Med, Shanghai 200025, Peoples R China |
| 第一作者单位 | 免疫化学研究所 |
| 通讯作者单位 | 免疫化学研究所 |
| 第一作者的第一单位 | 免疫化学研究所 |
| 推荐引用方式 GB/T 7714 | Huang, Qianping,Gu, Yuang,Qin, An,et al. FSO2N3-Mediated On-DNA Diazo-Transfer Chemistry[J]. ACS MEDICINAL CHEMISTRY LETTERS,2024,15(9). |
| APA | Huang, Qianping,Gu, Yuang,Qin, An,Ma, Peixiang,Xu, Hongtao,&Zhang, Shuning.(2024).FSO2N3-Mediated On-DNA Diazo-Transfer Chemistry.ACS MEDICINAL CHEMISTRY LETTERS,15(9). |
| MLA | Huang, Qianping,et al."FSO2N3-Mediated On-DNA Diazo-Transfer Chemistry".ACS MEDICINAL CHEMISTRY LETTERS 15.9(2024). |
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