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A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy | |
2024-08-07 | |
发表期刊 | CHEMICAL SCIENCE (IF:7.6[JCR-2023],8.0[5-Year]) |
ISSN | 2041-6520 |
EISSN | 2041-6539 |
卷号 | 15期号:31页码:12431-12441 |
发表状态 | 已发表 |
DOI | 10.1039/d4sc01915f |
摘要 | Singlet oxygen (O-1(2)), as a fundamental hallmark in photodynamic therapy (PDT), enables ground-breaking clinical treatment in ablating tumors and killing germs. However, accurate in vivo monitoring of O-1(2) remains a significant challenge in probe design, with primary difficulties arising from inherent photo-induced side reactions with poor selectivity. Herein, we report a generalizable zwitterionic strategy for ultra-stable near-infrared (NIR) chemiluminescent probes that ensure a highly specific [2 + 2] cycloaddition between fragile electron-rich enolether units and O-1(2) in both cellular and dynamic in vivo domains. Innovatively, zwitterionic chemiluminescence (CL) probes undergo a conversion into an inert ketone excited state with an extremely short lifetime through conical intersection (CI), thereby affording sufficient photostability and suppressing undesired photoreactions. Remarkably, compared with the well-known commercial O-1(2) probe SOSG, the zwitterionic probe QMI exhibited an ultra-high signal-to-noise ratio (SNR, over 40-fold). Of particular significance is that the zwitterionic CL probes demonstrate excellent selectivity, high sensitivity, and outstanding photostability, thereby making a breakthrough in real-time tracking of the FDA-approved 5-ALA-mediated in vivo PDT process in living mice. This innovative zwitterionic strategy paves a new pathway for high-performance NIR chemiluminescent probes and high-fidelity feedback on O-1(2) for future biological and medical applications. |
关键词 | Chemiluminescence Excited states Infrared devices Ketones Mammals Medical applications Oxygen Photodynamic therapy Signal to noise ratio Chemiluminescence probe Chemiluminescent probes In-vivo Near Infrared Near-infrared Photo-stability Phototherapy Selective sensing Singlet oxygen Zwitterionics |
URL | 查看原文 |
收录类别 | SCI ; EI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[ |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:001268237900001 |
出版者 | ROYAL SOC CHEMISTRY |
EI入藏号 | 20242816693143 |
EI主题词 | Probes |
EI分类号 | 461.6 Medicine and Pharmacology ; 716.1 Information Theory and Signal Processing ; 741.1 Light/Optics ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 804.1 Organic Compounds ; 931.3 Atomic and Molecular Physics ; 931.4 Quantum Theory ; Quantum Mechanics |
原始文献类型 | Article in Press |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/404257 |
专题 | 物质科学与技术学院 物质科学与技术学院_PI研究组_刘伟民组 |
通讯作者 | Guo, Zhiqian |
作者单位 | 1.East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem,Sch Che, Shanghai 200237, Peoples R China 2.Singapore Univ Technol & Design, Fluorescence Res Grp, 8 Somapah Rd, Singapore 487372, Singapore 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Yao,Zhang, Yutao,Wu, Xia,et al. A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy[J]. CHEMICAL SCIENCE,2024,15(31):12431-12441. |
APA | Lu, Yao.,Zhang, Yutao.,Wu, Xia.,Pu, Ruihua.,Yan, Chenxu.,...&Zhu, Wei-Hong.(2024).A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy.CHEMICAL SCIENCE,15(31),12431-12441. |
MLA | Lu, Yao,et al."A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy".CHEMICAL SCIENCE 15.31(2024):12431-12441. |
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