A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy
2024-08-07
发表期刊CHEMICAL SCIENCE (IF:7.6[JCR-2023],8.0[5-Year])
ISSN2041-6520
EISSN2041-6539
卷号15期号:31页码:12431-12441
发表状态已发表
DOI10.1039/d4sc01915f
摘要

Singlet oxygen (O-1(2)), as a fundamental hallmark in photodynamic therapy (PDT), enables ground-breaking clinical treatment in ablating tumors and killing germs. However, accurate in vivo monitoring of O-1(2) remains a significant challenge in probe design, with primary difficulties arising from inherent photo-induced side reactions with poor selectivity. Herein, we report a generalizable zwitterionic strategy for ultra-stable near-infrared (NIR) chemiluminescent probes that ensure a highly specific [2 + 2] cycloaddition between fragile electron-rich enolether units and O-1(2) in both cellular and dynamic in vivo domains. Innovatively, zwitterionic chemiluminescence (CL) probes undergo a conversion into an inert ketone excited state with an extremely short lifetime through conical intersection (CI), thereby affording sufficient photostability and suppressing undesired photoreactions. Remarkably, compared with the well-known commercial O-1(2) probe SOSG, the zwitterionic probe QMI exhibited an ultra-high signal-to-noise ratio (SNR, over 40-fold). Of particular significance is that the zwitterionic CL probes demonstrate excellent selectivity, high sensitivity, and outstanding photostability, thereby making a breakthrough in real-time tracking of the FDA-approved 5-ALA-mediated in vivo PDT process in living mice. This innovative zwitterionic strategy paves a new pathway for high-performance NIR chemiluminescent probes and high-fidelity feedback on O-1(2) for future biological and medical applications.

关键词Chemiluminescence Excited states Infrared devices Ketones Mammals Medical applications Oxygen Photodynamic therapy Signal to noise ratio Chemiluminescence probe Chemiluminescent probes In-vivo Near Infrared Near-infrared Photo-stability Phototherapy Selective sensing Singlet oxygen Zwitterionics
URL查看原文
收录类别SCI ; EI
语种英语
资助项目National Natural Science Foundation of China[
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:001268237900001
出版者ROYAL SOC CHEMISTRY
EI入藏号20242816693143
EI主题词Probes
EI分类号461.6 Medicine and Pharmacology ; 716.1 Information Theory and Signal Processing ; 741.1 Light/Optics ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 804.1 Organic Compounds ; 931.3 Atomic and Molecular Physics ; 931.4 Quantum Theory ; Quantum Mechanics
原始文献类型Article in Press
引用统计
正在获取...
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/404257
专题物质科学与技术学院
物质科学与技术学院_PI研究组_刘伟民组
通讯作者Guo, Zhiqian
作者单位
1.East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem,Sch Che, Shanghai 200237, Peoples R China
2.Singapore Univ Technol & Design, Fluorescence Res Grp, 8 Somapah Rd, Singapore 487372, Singapore
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714
Lu, Yao,Zhang, Yutao,Wu, Xia,et al. A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy[J]. CHEMICAL SCIENCE,2024,15(31):12431-12441.
APA Lu, Yao.,Zhang, Yutao.,Wu, Xia.,Pu, Ruihua.,Yan, Chenxu.,...&Zhu, Wei-Hong.(2024).A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy.CHEMICAL SCIENCE,15(31),12431-12441.
MLA Lu, Yao,et al."A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy".CHEMICAL SCIENCE 15.31(2024):12431-12441.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Lu, Yao]的文章
[Zhang, Yutao]的文章
[Wu, Xia]的文章
百度学术
百度学术中相似的文章
[Lu, Yao]的文章
[Zhang, Yutao]的文章
[Wu, Xia]的文章
必应学术
必应学术中相似的文章
[Lu, Yao]的文章
[Zhang, Yutao]的文章
[Wu, Xia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。