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ShanghaiTech University Knowledge Management System
Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively | |
2019-04-23 | |
发表期刊 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year]) |
ISSN | 1433-7851 |
卷号 | 58期号:18页码:6070-6073 |
发表状态 | 已发表 |
DOI | 10.1002/anie.201814519 |
摘要 | Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells. |
关键词 | anticancer copper redox chemistry sulfides zinc |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[U1532125] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:000465413400046 |
出版者 | WILEY-V C H VERLAG GMBH |
EI入藏号 | 20191306695413 |
EI主题词 | Copper ; Oxidants ; Proteins ; Sulfur compounds ; Zinc ; Zinc compounds |
WOS关键词 | COPPER ; COORDINATION ; SPECTROSCOPY ; BIOCHEMISTRY ; STRESS ; CANCER |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/37512 |
专题 | 物质科学与技术学院_本科生 物质科学与技术学院_PI研究组_林柏霖组 物质科学与技术学院_公共科研平台_分析测试平台 物质科学与技术学院_硕士生 |
通讯作者 | Deng, Wei; Wang, Yu; Lin, Bo-Lin |
作者单位 | 1.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China 3.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
第一作者的第一单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Xu, Luyan,Xu, Jialin,Zhu, Jingwei,et al. Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(18):6070-6073. |
APA | Xu, Luyan.,Xu, Jialin.,Zhu, Jingwei.,Yao, Zijian.,Yu, Na.,...&Lin, Bo-Lin.(2019).Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(18),6070-6073. |
MLA | Xu, Luyan,et al."Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.18(2019):6070-6073. |
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