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Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively
2019-04-23
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN1433-7851
卷号58期号:18页码:6070-6073
发表状态已发表
DOI10.1002/anie.201814519
摘要Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.
关键词anticancer copper redox chemistry sulfides zinc
收录类别SCI ; SCIE ; EI
语种英语
资助项目National Natural Science Foundation of China[U1532125]
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000465413400046
出版者WILEY-V C H VERLAG GMBH
EI入藏号20191306695413
EI主题词Copper ; Oxidants ; Proteins ; Sulfur compounds ; Zinc ; Zinc compounds
WOS关键词COPPER ; COORDINATION ; SPECTROSCOPY ; BIOCHEMISTRY ; STRESS ; CANCER
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/37512
专题物质科学与技术学院_本科生
物质科学与技术学院_PI研究组_林柏霖组
物质科学与技术学院_公共科研平台_分析测试平台
物质科学与技术学院_硕士生
通讯作者Deng, Wei; Wang, Yu; Lin, Bo-Lin
作者单位
1.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
2.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China
3.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
第一作者的第一单位物质科学与技术学院
推荐引用方式
GB/T 7714
Xu, Luyan,Xu, Jialin,Zhu, Jingwei,et al. Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(18):6070-6073.
APA Xu, Luyan.,Xu, Jialin.,Zhu, Jingwei.,Yao, Zijian.,Yu, Na.,...&Lin, Bo-Lin.(2019).Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(18),6070-6073.
MLA Xu, Luyan,et al."Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.18(2019):6070-6073.
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