Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively

doi:10.1002/anie.201814519

	Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively
	Xu, Luyan1,4,5 ; Xu, Jialin1 ; Zhu, Jingwei 3; Yao, Zijian 3; Yu, Na1 ; Deng, Wei 3; Wang, Yu 2; Lin, Bo-Lin1,4,5
	2019-04-23
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN	1433-7851
卷号	58 期号:18 页码:6070-6073
发表状态	已发表
DOI	10.1002/anie.201814519
摘要	Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.
关键词	anticancer copper redox chemistry sulfides zinc
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Natural Science Foundation of China[U1532125]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000465413400046
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20191306695413
EI主题词	Copper ; Oxidants ; Proteins ; Sulfur compounds ; Zinc ; Zinc compounds
WOS关键词	COPPER ; COORDINATION ; SPECTROSCOPY ; BIOCHEMISTRY ; STRESS ; CANCER
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/37512
专题	物质科学与技术学院_本科生物质科学与技术学院_PI研究组_林柏霖组物质科学与技术学院_公共科研平台_分析测试平台物质科学与技术学院_硕士生
通讯作者	Deng, Wei; Wang, Yu; Lin, Bo-Lin
作者单位	1.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China 3.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Xu, Luyan,Xu, Jialin,Zhu, Jingwei,et al. Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(18):6070-6073.
APA	Xu, Luyan.,Xu, Jialin.,Zhu, Jingwei.,Yao, Zijian.,Yu, Na.,...&Lin, Bo-Lin.(2019).Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(18),6070-6073.
MLA	Xu, Luyan,et al."Universal Anticancer Cu(DTC)(2) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.18(2019):6070-6073.