Tonic-ing emissions and compatibility to turbocharge CAR-T

doi:10.1038/s42255-024-01022-x

	Tonic-ing emissions and compatibility to turbocharge CAR-T
	Wang, Haopeng1,2,3 ; Huang, Yuwei1,4 ; Wang, Ruoning 5,6
	2024-04-01
发表期刊	NATURE METABOLISM (IF:18.9[JCR-2023],21.0[5-Year])
ISSN	2522-5812
EISSN	2522-5812
发表状态	已发表
DOI	10.1038/s42255-024-01022-x
摘要	Optimization of energy and carbon-nitrogen allocation maximizes the proliferation and functionality of chimeric antigen receptor (CAR)-T cells. Lakhani et al. report that tonic signalling elements (scFvs) affect CAR-T cell metabolic fitness in an antigen-independent manner. A modest carbon-nitrogen emission (overflow) and resilient metabolic phenotype (compatibility) are associated with effective CAR-T cell therapy.
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:001207608800002
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/372807
专题	生命科学与技术学院生命科学与技术学院_PI研究组_王皞鹏组生命科学与技术学院_博士生
通讯作者	Wang, Haopeng; Wang, Ruoning
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 2.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai, Peoples R China 3.Shanghai Clin Res & Trial Ctr, Shanghai, Peoples R China 4.Lingang Lab, Shanghai, Peoples R China 5.Ohio State Univ, Nationwide Childrens Hosp, Abigail Wexner Res Inst, Dept Pediat,BMT, Columbus, OH 43210 USA 6.Ohio State Univ, Ctr Childhood Canc Res Hematol Oncol, Columbus, OH 43210 USA
第一作者单位	生命科学与技术学院; 上海科技大学
通讯作者单位	生命科学与技术学院; 上海科技大学
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Haopeng,Huang, Yuwei,Wang, Ruoning. Tonic-ing emissions and compatibility to turbocharge CAR-T[J]. NATURE METABOLISM,2024.
APA	Wang, Haopeng,Huang, Yuwei,&Wang, Ruoning.(2024).Tonic-ing emissions and compatibility to turbocharge CAR-T.NATURE METABOLISM.
MLA	Wang, Haopeng,et al."Tonic-ing emissions and compatibility to turbocharge CAR-T".NATURE METABOLISM (2024).