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ShanghaiTech University Knowledge Management System
Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions | |
2024-04-24 | |
发表期刊 | ANGEWANDTE CHEMIE - INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year]) |
ISSN | 1433-7851 |
EISSN | 1521-3773 |
卷号 | 63期号:18 |
发表状态 | 已发表 |
DOI | 10.1002/anie.202401671 |
摘要 | The rapid assembly of valuable cyclic amine architectures in a single step from simple precursors has been recognized as an ideal platform in term of efficiency and sustainability. Although a vast number of studies regarding cyclic amine synthesis has been reported, new synthetic disconnection approaches are still high in demand. Herein, we report a catalytic radical-polar crossover cycloaddition to cyclic amine synthesis triggered from primary sulfonamide under photoredox condition. This newly developed disconnection, comparable to established synthetic approaches, will allow to construct β, β-disubstituted cyclic amine and β-monosubstituted cyclic amine derivatives efficiently. This study highlights the unique utility of primary sulfonamide as a bifunctional reagent, which acts as a radical precursor and a nucleophile. The open-shell methodology demonstrates broad tolerance to various functional groups, drug derivatives and natural products in an economically and sustainable fashion. © 2024 Wiley-VCH GmbH. |
关键词 | Drug products Sulfur compounds Amine synthesis Bifunctional reagents Condition Cyclic amines Cycloadditions Radical Radical-polar Simple++ Single-step Sulphonamides |
URL | 查看原文 |
收录类别 | EI ; SCI |
语种 | 英语 |
资助项目 | null[22201179] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:001185234800001 |
出版者 | John Wiley and Sons Inc |
EI入藏号 | 20241215754274 |
EI主题词 | Cycloaddition |
EI分类号 | 802.2 Chemical Reactions |
原始文献类型 | Article in Press |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/359852 |
专题 | 物质科学与技术学院 物质科学与技术学院_硕士生 物质科学与技术学院_博士生 物质科学与技术学院_PI研究组_黄焕明组 |
通讯作者 | Huang, Huan-Ming |
作者单位 | School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai; 201210, China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
第一作者的第一单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Zhang, Ying,Chen, Shu-Sheng,Li, Kai-Dian,et al. Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions[J]. ANGEWANDTE CHEMIE - INTERNATIONAL EDITION,2024,63(18). |
APA | Zhang, Ying,Chen, Shu-Sheng,Li, Kai-Dian,&Huang, Huan-Ming.(2024).Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions.ANGEWANDTE CHEMIE - INTERNATIONAL EDITION,63(18). |
MLA | Zhang, Ying,et al."Cyclic Amine Synthesis via Catalytic Radical-Polar Crossover Cycloadditions".ANGEWANDTE CHEMIE - INTERNATIONAL EDITION 63.18(2024). |
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