Dorsomedial hypothalamic BDNF neurons integrate thermal afferent signals to control energy expenditure

doi:10.1101/2021.04.11.439314

	Dorsomedial hypothalamic BDNF neurons integrate thermal afferent signals to control energy expenditure
	Zhou, Q.1,2,3,4 ; Bian, H.1,2,3,4 ; Wang, M.1,2,3,4 ; Ni, X.1 ; Yang, W. Z.1,5; Sun, H.1 ; Shen, W. L.1
	2021-04-11
状态	已发表
摘要	Mutations in the gene brain-derived neurotrophic factor (BDNF) cause obesity in humans. BDNF signaling and its expressing neurons in the hypothalamus help control feeding, energy expenditure (EE), and physical activity. However, whether the BDNF neurons interact with another EE-regulating system, the thermoregulation circuitry, remains unclear. Here, we show that BDNF neurons in the dorsomedial hypothalamus (DMH) are activated by environmental cooling and sufficient to induce body temperature increases and brown adipose tissue (BAT) thermogenesis. Conversely, blocking these neurons impairs BAT thermogenesis and cold defense, causing body weight gain and glucose intolerance. DMH BDNF neurons are therefore an important type of thermoregulatory neuron, integrating thermal afferent signals to control EE during cold defense. This reveals a critical intersection between the BDNF circuitry and the thermoregulatory system.
关键词	thermoregulation BDNF BAT thermogenesis energy expenditure.
语种	英语
DOI	10.1101/2021.04.11.439314
相关网址	查看原文
出处	bioRxiv
收录类别	PPRN.PPRN
WOS记录号	PPRN:8848194
WOS类目	Neurosciences
资助项目	National Nature Science Foundation of China["19140903800","NYKFKT20190017","2019M651616","31900707"] ; China Postdoctoral Science Foundation[31771169] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[91857104]
文献类型	预印本
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/348517
专题	生命科学与技术学院生命科学与技术学院_PI研究组_沈伟组生命科学与技术学院_博士生
通讯作者	Sun, H.; Shen, W. L.
作者单位	1.Shanghaitech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Q.,Bian, H.,Wang, M.,et al. Dorsomedial hypothalamic BDNF neurons integrate thermal afferent signals to control energy expenditure. 2021.