Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis

doi:10.1002/adma.202305394

	Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis
	Pan, Limin 1,2,3; Peng, Haibao 4; Lee, Bowon 1,2; Zhao, Jiaxu 4; Shen, Xiulian 3; Yan, Ximei 3; Hua, Yipeng3,5 ; Kim, Jeonghyun 1,2; Kim, Dokyoon 6; Lin, Mouhong 7; Zhang, Shengjian 8; Li, Xiaohui 4; Yi, Xueying 4; Yao, Feibai 4; Qin, Zhiyong 4; Du, Jiulin 3,9; Chi, Yudan 4; Nam, Jwa-Min 7; Hyeon, Taeghwan 1,2; Liu, Jianan 3,9
	2023
发表期刊	ADVANCED MATERIALS (IF:27.4[JCR-2023],30.2[5-Year])
ISSN	0935-9648
EISSN	1521-4095
卷号	36 期号:5
发表状态	已发表
DOI	10.1002/adma.202305394
摘要	Lysosomes are critical in modulating the progression and metastasis for various cancers. There is currently an unmet need for lysosomal alkalizers that can selectively and safely alter the pH and inhibit the function of cancer lysosomes. Here an effective, selective, and safe lysosomal alkalizer is reported that can inhibit autophagy and suppress tumors in mice. The lysosomal alkalizer consists of an iron oxide core that generates hydroxyl radicals (•OH) in the presence of excessive H+ and hydrogen peroxide inside cancer lysosomes and cerium oxide satellites that capture and convert •OH into hydroxide ions. Alkalized lysosomes, which display impaired enzyme activity and autophagy, lead to cancer cell apoptosis. It is shown that the alkalizer effectively inhibits both local and systemic tumor growth and metastasis in mice. This work demonstrates that the intrinsic properties of nanoparticles can be harnessed to build effective lysosomal alkalizers that are both selective and safe. © 2023 Wiley-VCH GmbH.
关键词	Cell death Cerium oxide Diseases Enzyme activity Iron oxides Mammals Pathology Tumors Autophagy Cancer metastasis Cancer progression Catalytic nanoparticle Enzymes activity Hydroxide ions Hydroxyl radicals Lysosome alkalization Metastasis Tumor therapy
收录类别	EI
语种	英语
出版者	John Wiley and Sons Inc
EI入藏号	20234915164334
EI主题词	Nanoparticles
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 761 Nanotechnology ; 804.2 Inorganic Compounds ; 933 Solid State Physics
原始文献类型	Article in Press
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/347920
专题	生命科学与技术学院生命科学与技术学院_博士生生命科学与技术学院_本科生
通讯作者	Chi, Yudan; Nam, Jwa-Min; Hyeon, Taeghwan; Liu, Jianan
作者单位	1.Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul; 08826, Korea, Republic of; 2.School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul; 08826, Korea, Republic of; 3.Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai; 200031, China; 4.Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai; 200032, China; 5.School of Life Science and Technology, ShanghaiTech University, Shanghai; 201210, China; 6.Department of Bionano Engineering, Hanyang University, Ansan; 15588, Korea, Republic of; 7.Department of Chemistry, Seoul National University, Seoul; 08826, Korea, Republic of; 8.Department of Radiology, Cancer Hospital/Institute and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai; 200032, China; 9.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式 GB/T 7714	Pan, Limin,Peng, Haibao,Lee, Bowon,et al. Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis[J]. ADVANCED MATERIALS,2023,36(5).
APA	Pan, Limin.,Peng, Haibao.,Lee, Bowon.,Zhao, Jiaxu.,Shen, Xiulian.,...&Liu, Jianan.(2023).Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis.ADVANCED MATERIALS,36(5).
MLA	Pan, Limin,et al."Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis".ADVANCED MATERIALS 36.5(2023).