上海科技大学知识管理系统

1,3-Bis(boronic) esters can be readily synthesized from alkylBpin precursors. Selectivetransformations of these compounds hold the potential for latestage functionalization of the remaining C-B bond, leading to a diversearray of molecules.Currently,there are no strategies available to address the reactivity and,more importantly,the controllable regiodivergent functionalization of 1,3-bis(boronic)esters. In this study,we have achieved controllable regiodivergent alkynylation of these molecules.The regioselectivity has been clarified based on the unique chelation patterns observed with different organometallic reagents.Remarkably, this methodology effectively addresses the low reactivity of 1,3-bis(boronic)esters and bridges the gap in radical chemistry,which typically yields only the classical products formed via stable radical intermediates. Furthermore,the compounds synthesized through this approach serve as potent building blocks for creating molecular diversity.