Mesostructured Fibrils Exfoliated in Deep Eutectic Solvent as Building Blocks of Collagen Membranes

doi:10.3390/polym15194008

	Mesostructured Fibrils Exfoliated in Deep Eutectic Solvent as Building Blocks of Collagen Membranes
	Pei, Ying 1,2,3; Li, Wei 3; Wang, Lu 3; Cui, Jing4 ; Li, Lu 1; Ling, Shengjie4 ; Tang, Keyong 3; Tian, Huafeng 2
	2023-10
发表期刊	POLYMERS
EISSN	2073-4360
卷号	15 期号:19
发表状态	已发表
DOI	10.3390/polym15194008
摘要	The mesoscale components of collagen (nanofibrils, fibrils, and fiber bundles) are well organized in native tissues, resulting in superior properties and diverse functions. In this paper, we present a simple and controlled liquid exfoliation method to directly extract medium-sized collagen fibers ranging from 102 to 159 nm in diameter from bovine Achilles tendon using urea/hydrochloric acid and a deep eutectic solvent (DES). In situ observations under polarized light microscopy (POM) and molecular dynamics simulations revealed the effects of urea and GuHCl on tendon collagen. FTIR study results confirmed that these fibrils retained the typical structural characteristics of type I collagen. These shed collagen fibrils were then used as building blocks to create independent collagen membranes with good and stable mechanical properties, excellent barrier properties, and cell compatibility. A new method for collagen processing is provided in this work by using DES-assisted liquid exfoliation for constructing robust collagen membranes with mesoscale collagen fibrils as building blocks. © 2023 by the authors.
关键词	Biomechanics Collagen Eutectics Mammals Metabolism Molecular dynamics Solvents Tendons Achilles tendons Bovine achilles tendon Building blockes Collagen fibrils Collagen membrane Deep eutectic solvents Exfoliation Fibril Liquid exfoliations Mesostructured
URL	查看原文
收录类别	EI ; SCI
语种	英语
WOS研究方向	Polymer Science
WOS类目	Polymer Science
WOS记录号	WOS:001081556000001
出版者	Multidisciplinary Digital Publishing Institute (MDPI)
EI入藏号	20234214906695
EI主题词	Urea
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.3 Biomechanics, Bionics and Biomimetics ; 531.2 Metallography ; 801.4 Physical Chemistry ; 803 Chemical Agents and Basic Industrial Chemicals ; 804.1 Organic Compounds
原始文献类型	Journal article (JA)
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/340973
专题	物质科学与技术学院物质科学与技术学院_外聘教师物质科学与技术学院_PI研究组_凌盛杰组
通讯作者	Pei, Ying; Ling, Shengjie; Tian, Huafeng
作者单位	1.Shaanxi Univ Sci & Technol, Minist Educ, Key Lab Auxiliary Chem & Technol Chem Ind, Xian 710021, Peoples R China 2.Beijing Technol & Business Univ, China Natl Light Ind Council, Key Lab Proc & Qual Evaluat Technol Green Plast, Beijing 100048, Peoples R China 3.Zhengzhou Univ, Coll Mat Sci & Engn, Zhengzhou 450001, Peoples R China 4.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Pei, Ying,Li, Wei,Wang, Lu,et al. Mesostructured Fibrils Exfoliated in Deep Eutectic Solvent as Building Blocks of Collagen Membranes[J]. POLYMERS,2023,15(19).
APA	Pei, Ying.,Li, Wei.,Wang, Lu.,Cui, Jing.,Li, Lu.,...&Tian, Huafeng.(2023).Mesostructured Fibrils Exfoliated in Deep Eutectic Solvent as Building Blocks of Collagen Membranes.POLYMERS,15(19).
MLA	Pei, Ying,et al."Mesostructured Fibrils Exfoliated in Deep Eutectic Solvent as Building Blocks of Collagen Membranes".POLYMERS 15.19(2023).