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| Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens | |
| 2023-09-28 | |
| Source Publication | FRONTIERS IN PHARMACOLOGY
 |
| EISSN | 1663-9812 |
| Volume | 14 |
| Status | 已发表 |
| DOI | 10.3389/fphar.2023.1279512 |
| Abstract | With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: 1) Different types of nicotine salts could increase the release of DA in the NAc. 2) The slopes and half-effective concentrations of the fitted curves were different, suggesting that each nicotine salt had a difference in the efficiency of increasing DA release with concentration changes. 3) The absorption rates of different nicotine salts containing the same original nicotine concentration were significantly different by measuring the blood nicotine content. The effect of nicotine salts on increasing DA was directly proportional to the blood nicotine level. In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain. |
| Keyword | nicotine nicotine salts dopamine nucleus accumbens satisfaction |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| WOS ID | WOS:001079378400001 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/340918 |
| Collection | 生命科学与技术学院 生命科学与技术学院_PI研究组_胡霁组 |
| Corresponding Author | Chen, Ming; Ru, Jiexiong; Gao, Yihan |
| Affiliation | 1.Shanghai New Tobacco Prod Res Inst Co Ltd, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Fudan Univ, Inst Brain Sci, MOE Frontier Ctr Brain Sci, Shanghai, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Li, Xiaonan,Lu, Lehua,He, Ying,et al. Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens[J]. FRONTIERS IN PHARMACOLOGY,2023,14. |
| APA | Li, Xiaonan.,Lu, Lehua.,He, Ying.,Zhang, Hui.,Zhang, Yihui.,...&Gao, Yihan.(2023).Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens.FRONTIERS IN PHARMACOLOGY,14. |
| MLA | Li, Xiaonan,et al."Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens".FRONTIERS IN PHARMACOLOGY 14(2023). |
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