Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
2023-09-28
Source PublicationFRONTIERS IN PHARMACOLOGY
EISSN1663-9812
Volume14
Status已发表
DOI10.3389/fphar.2023.1279512
AbstractWith the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: 1) Different types of nicotine salts could increase the release of DA in the NAc. 2) The slopes and half-effective concentrations of the fitted curves were different, suggesting that each nicotine salt had a difference in the efficiency of increasing DA release with concentration changes. 3) The absorption rates of different nicotine salts containing the same original nicotine concentration were significantly different by measuring the blood nicotine content. The effect of nicotine salts on increasing DA was directly proportional to the blood nicotine level. In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain.
Keywordnicotine nicotine salts dopamine nucleus accumbens satisfaction
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Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:001079378400001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/340918
Collection生命科学与技术学院
生命科学与技术学院_PI研究组_胡霁组
Corresponding AuthorChen, Ming; Ru, Jiexiong; Gao, Yihan
Affiliation
1.Shanghai New Tobacco Prod Res Inst Co Ltd, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Fudan Univ, Inst Brain Sci, MOE Frontier Ctr Brain Sci, Shanghai, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Li, Xiaonan,Lu, Lehua,He, Ying,et al. Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens[J]. FRONTIERS IN PHARMACOLOGY,2023,14.
APA Li, Xiaonan.,Lu, Lehua.,He, Ying.,Zhang, Hui.,Zhang, Yihui.,...&Gao, Yihan.(2023).Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens.FRONTIERS IN PHARMACOLOGY,14.
MLA Li, Xiaonan,et al."Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens".FRONTIERS IN PHARMACOLOGY 14(2023).
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