Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens

doi:10.3389/fphar.2023.1279512

	Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
	Li, Xiaonan 1; Lu, Lehua 1; He, Ying 1; Zhang, Hui 1; Zhang, Yihui 1; Sheng, Huaquan 1; Chen, Ming2,3 ; Ru, Jiexiong 1; Gao, Yihan 1
	2023-09-28
发表期刊	FRONTIERS IN PHARMACOLOGY (IF:4.4[JCR-2023],5.0[5-Year])
EISSN	1663-9812
卷号	14
发表状态	已发表
DOI	10.3389/fphar.2023.1279512
摘要	With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: 1) Different types of nicotine salts could increase the release of DA in the NAc. 2) The slopes and half-effective concentrations of the fitted curves were different, suggesting that each nicotine salt had a difference in the efficiency of increasing DA release with concentration changes. 3) The absorption rates of different nicotine salts containing the same original nicotine concentration were significantly different by measuring the blood nicotine content. The effect of nicotine salts on increasing DA was directly proportional to the blood nicotine level. In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain.
关键词	nicotine nicotine salts dopamine nucleus accumbens satisfaction
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:001079378400001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/340918
专题	生命科学与技术学院生命科学与技术学院_PI研究组_胡霁组
通讯作者	Chen, Ming; Ru, Jiexiong; Gao, Yihan
作者单位	1.Shanghai New Tobacco Prod Res Inst Co Ltd, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Fudan Univ, Inst Brain Sci, MOE Frontier Ctr Brain Sci, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Xiaonan,Lu, Lehua,He, Ying,et al. Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens[J]. FRONTIERS IN PHARMACOLOGY,2023,14.
APA	Li, Xiaonan.,Lu, Lehua.,He, Ying.,Zhang, Hui.,Zhang, Yihui.,...&Gao, Yihan.(2023).Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens.FRONTIERS IN PHARMACOLOGY,14.
MLA	Li, Xiaonan,et al."Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens".FRONTIERS IN PHARMACOLOGY 14(2023).