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Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5
作者:  Wang, Manjiong;  Tang, Tongke;  Li, Ruoxi;  Huang, Zhenghui;  Ling, Dazheng
Adobe PDF(7159Kb)  |  收藏  |  浏览/下载:228/0  |  提交时间:2022/04/12
Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents 期刊论文
CHINESE CHEMICAL LETTERS, 2021, 卷号: 32, 期号: 5, 页码: 1660-1664
作者:  Li, Ruoxi;  Ling, Dazheng;  Tang, Tongke;  Huang, Zhenghui;  Wang, Manjiong
Adobe PDF(1122Kb)  |  收藏  |  浏览/下载:208/0  |  提交时间:2021/05/28
Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 4, 页码: 2254-2271
作者:  Li, Ruoxi;  Ling, Dazheng;  Tang, Tongke;  Huang, Zhenghui;  Wang, Manjiong
Adobe PDF(4915Kb)  |  收藏  |  浏览/下载:313/0  |  提交时间:2021/04/01
A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1 期刊论文
CELL DISCOVERY, 2020, 卷号: 6, 期号: 1
作者:  Huang, Zhenghui;  Li, Ruoxi;  Tang, Tongke;  Ling, Dazheng;  Wang, Manjiong
Adobe PDF(2805Kb)  |  收藏  |  浏览/下载:685/229  |  提交时间:2021/01/19
Two conserved epigenetic regulators prevent healthy ageing 期刊论文
NATURE, 2020
作者:  Yuan, Jie;  Chang, Si-Yuan;  Yin, Shi-Gang;  Liu, Zhi-Yang;  Cheng, Xiu
Adobe PDF(10283Kb)  |  收藏  |  浏览/下载:662/0  |  提交时间:2020/03/27
The cryptic unstable transcripts are associated with developmentally regulated gene expression in blood-stage Plasmodium falciparum 期刊论文
RNA BIOLOGY, 2020
作者:  Yin, Shigang;  Fan, Yanting;  He, Xiaohui;  Wei, Guiying;  Wen, Yuhao
Adobe PDF(6948Kb)  |  收藏  |  浏览/下载:617/0  |  提交时间:2020/03/16
环状或螺环二胺类嘧啶-异羟肟酸及其用途 专利
申请号:201910212087 .1,申请日期: 2019-03-20,
发明人:  李健;  江陆斌;  李若曦;  黄正辉;  汤同柯
Adobe PDF(5320Kb)  |  收藏  |  浏览/下载:165/0  |  提交时间:2022/08/23
2 ,8-二氮杂-螺-[4 ,5]-癸烷类嘧啶-异羟肟 酸化合物及其用途 专利
申请号:201910214972 .3,申请日期: 2019-03-20,
发明人:  李剑;  江陆斌;  李若曦;  汤同柯;  黄正辉
Adobe PDF(6124Kb)  |  收藏  |  浏览/下载:202/0  |  提交时间:2022/08/23
DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 8, 页码: 3177-3182
作者:  Li, Zhou;  Yin, Shigang;  Sun, Maoxin;  Cheng, Xiu;  Wei, Jieqiong
Adobe PDF(1619Kb)  |  收藏  |  浏览/下载:469/5  |  提交时间:2019/03/12
Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 1, 页码: 255-260
作者:  Xiao, Bo;  Yin, Shigang;  Hu, Yang;  Sun, Maoxin;  Wei, Jieqiong
Adobe PDF(1496Kb)  |  收藏  |  浏览/下载:446/2  |  提交时间:2019/01/18