Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease

doi:10.1016/j.scr.2023.103091

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	Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease
	Huang, Juan 1; Wang, Ying2,4 ; Zhao, Jian2,3,4 ; Deng, Yulei 5,6; Wei, Wenshi 1
	2023-06-01
发表期刊	STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN	1873-5061
EISSN	1876-7753
卷号	69
发表状态	已发表
DOI	10.1016/j.scr.2023.103091
摘要	A 62-years old Alzheimer's disease (AD) male patient donated his Peripheral blood mononuclear cells. The non-integrating episomal vector system used to reprogram PBMCs with Oct3/4, Klf4, Sox2 and c-Myc transcription factors. The pluripotency of transgene-free pluripotent stem cell (iPSC) was confirmed by immunocyto-chemistry for pluripotency markers-SOX2, NANOG, OCT3/4, SSEA4, TRA1-60, and TRA1-81. The differentiation capacity of the iPSCs into endoderm, mesoderm and ectoderm was assessed by AFP, SMA and beta III-TUBULIN, respectively. In addition, the iPSC line displayed a normal karyotype. This iPSC line might offer a good cell model to explore the pathological mechanisms and treatment strategies for AD.
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[YDZX2021310001684] ; National Natural Science Foundation of China[:31871408] ; Shanghai Municipal Health Commission[:2020YJZX0109]
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology
WOS记录号	WOS:001004401000001
出版者	ELSEVIER
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/312311
专题	免疫化学研究所生命科学与技术学院免疫化学研究所_PI研究组_赵简组
通讯作者	Deng, Yulei; Wei, Wenshi
作者单位	1.Fudan Univ, Huadong Hosp, Neurol Dept, Shanghai, Peoples R China 2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Lab Regenerat Med & Neural Repair, Shanghai 201210, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Shanghai, Peoples R China 6.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Neurol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Huang, Juan,Wang, Ying,Zhao, Jian,et al. Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease[J]. STEM CELL RESEARCH,2023,69.
APA	Huang, Juan,Wang, Ying,Zhao, Jian,Deng, Yulei,&Wei, Wenshi.(2023).Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease.STEM CELL RESEARCH,69.
MLA	Huang, Juan,et al."Establishment of an induced pluripotent stem cell (SIAISi016-A) line from a 62-years old Chinese Han patient with Alzheimer's disease".STEM CELL RESEARCH 69(2023).