Nanocatalytic Tumor Therapy by Single-Atom Catalysts

doi:10.1021/acsnano.9b00457

	Nanocatalytic Tumor Therapy by Single-Atom Catalysts
	Huo, Minfeng 1,2; Wang, Liying1,2,3 ; Wang, Youwei 1; Chen, Yu 1; Shi, Jianlin1
	2019-02
发表期刊	ACS NANO (IF:15.8[JCR-2023],16.2[5-Year])
ISSN	1936-0851
卷号	13 期号:2 页码:2643-2653
发表状态	已发表
DOI	10.1021/acsnano.9b00457
摘要	Initiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the high performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger the in situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (center dot OH) selectively under the acidic TME. Based on density functional theory, it has been theoretically uncovered that the nanocatalysts could specifically catalyze the heterogeneous Fenton reaction via a proton-mediated H2O2-homolytic pathway. These generated radicals could not only lead to the apoptotic cell death of malignant tumors, but also induce the accumulation of lipid peroxides, causing tumor cell ferroptosis, which synergistically lead to an impressive tumor suppression outcome. In the meantime, the favorable biodegradability and biocompatibility of PSAF NCs also guarantee their desirable biosafety both in vivo and in vitro.
关键词	single-atom catalyst nanocatalytic medicine tumor nanotherapy heterogeneous Fenton reaction photothermal effect
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Program of Shanghai Academic Research Leader[18XD1404300]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000460199400164
出版者	AMER CHEMICAL SOC
EI入藏号	20192407039584
EI主题词	Atoms ; Biocompatibility ; Biodegradability ; Biohazards ; Cell death ; Density functional theory ; Iron compounds ; Nanocatalysts ; Oxidation
EI分类号	Bioengineering and Biology:461 ; Biochemistry:801.2 ; Chemical Reactions:802.2 ; Accidents and Accident Prevention:914.1 ; Atomic and Molecular Physics:931.3
WOS关键词	OXYGEN REDUCTION ; HYDROGEN-PEROXIDE ; CANCER ; IRON ; FERROPTOSIS ; ELECTROCATALYST ; METABOLISM ; MECHANISMS ; CELLS ; OXIDE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30551
专题	物质科学与技术学院_博士生物质科学与技术学院_特聘教授组_施剑林组
通讯作者	Chen, Yu; Shi, Jianlin
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Huo, Minfeng,Wang, Liying,Wang, Youwei,et al. Nanocatalytic Tumor Therapy by Single-Atom Catalysts[J]. ACS NANO,2019,13(2):2643-2653.
APA	Huo, Minfeng,Wang, Liying,Wang, Youwei,Chen, Yu,&Shi, Jianlin.(2019).Nanocatalytic Tumor Therapy by Single-Atom Catalysts.ACS NANO,13(2),2643-2653.
MLA	Huo, Minfeng,et al."Nanocatalytic Tumor Therapy by Single-Atom Catalysts".ACS NANO 13.2(2019):2643-2653.