Expression profiles of east-west highly differentiated genes in Uyghur genomes

doi:10.1093/nsr/nwad077

	Expression profiles of east-west highly differentiated genes in Uyghur genomes
	Ning, Zhilin 1; Tan, Xinjiang 1; Yuan, Yuan 1; Huang, Ke1,2 ; Pan, Yuwen 1; Tian, Lei 1; Lu, Yan 3; Wang, Xiaoji 1; Qi, Ruicheng 1; Lu, Dongsheng 1; Yang, Yajun 3; Guan, Yaqun 6; Mamatyusupu, Dolikun 7; Xu, Shuhua 3,4,5,8
	2023-03-21
发表期刊	NATIONAL SCIENCE REVIEW (IF:16.3[JCR-2023],18.6[5-Year])
ISSN	2095-5138
EISSN	2053-714X
卷号	10 期号:4
发表状态	已发表
DOI	10.1093/nsr/nwad077
摘要	["It remains unknown and debatable how European-Asian-differentiated alleles affect individual phenotypes. Here, we made the first effort to analyze the expression profiles of highly differentiated genes with eastern and western origins in 90 Uyghurs using whole-genome (30x to 60x) and transcriptome data. We screened 921 872 east-west highly differentiated genetic variants, of which similar to 4.32% were expression quantitative trait loci (eQTLs), similar to 0.12% were alternative splicing quantitative trait loci (sQTLs), and similar to 0.12% showed allele-specific expression (ASE). The 8305 highly differentiated eQTLs of strong effects appear to have undergone natural selection, associated with immunity and metabolism. European-origin alleles tend to be more biasedly expressed; highly differentiated ASEs were enriched in diabetes-associated genes, likely affecting the diabetes susceptibility in the Uyghurs. We proposed an admixture-induced expression model to dissect the highly differentiated expression profiles. We provide new insights into the genetic basis of phenotypic differentiation between Western and Eastern populations, advancing our understanding of the impact of genetic admixture.","East-west differentiated gene expression profiles."]
关键词	gene expression RNASeq Xinjiang's Uyghurs next-generation sequencing
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000981083700002
出版者	OXFORD UNIV PRESS
EI入藏号	20233114468450
EI主题词	Gene expression
EI分类号	461.9 Biology
原始文献类型	Journal article (JA)
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/305024
专题	生命科学与技术学院生命科学与技术学院_硕士生
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Computat Biol, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, State Key Lab Genet Engn,Ctr Evolutionary Biol, Shanghai 200438, Peoples R China 4.Fudan Univ, Human Phenome Inst, Zhangjiang Fudan Int Innovat Ctr, Shanghai 201203, Peoples R China 5.Fudan Univ, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 201203, Peoples R China 6.Xinjiang Med Univ, Preclin Med Coll, Dept Biochem & Mol Biol, Urumqi 830011, Peoples R China 7.Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China 8.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Ning, Zhilin,Tan, Xinjiang,Yuan, Yuan,et al. Expression profiles of east-west highly differentiated genes in Uyghur genomes[J]. NATIONAL SCIENCE REVIEW,2023,10(4).
APA	Ning, Zhilin.,Tan, Xinjiang.,Yuan, Yuan.,Huang, Ke.,Pan, Yuwen.,...&Xu, Shuhua.(2023).Expression profiles of east-west highly differentiated genes in Uyghur genomes.NATIONAL SCIENCE REVIEW,10(4).
MLA	Ning, Zhilin,et al."Expression profiles of east-west highly differentiated genes in Uyghur genomes".NATIONAL SCIENCE REVIEW 10.4(2023).