Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer

doi:10.1039/c8cc08753a

	Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer
	Liu, Wenyan 1,2,3; Zhang, Zhang 1,2,3; Zhang, Zhi-Min 1,2,3; Hao, Piliang4 ; Ding, Ke 1,2,3; Li, Zhengqiu 1,2,3
	2019-02-07
发表期刊	CHEMICAL COMMUNICATIONS (IF:4.3[JCR-2023],4.4[5-Year])
ISSN	1359-7345
卷号	55 期号:11 页码:1596-1599
发表状态	已发表
DOI	10.1039/c8cc08753a
摘要	Pancreatic cancer has been defined as one of the most complex and challenging cancers to treat, but very few valid therapeutic targets have been identified to date. To address this issue, a 61-compound library was readily created by Ugi reaction followed by phenotypic screening, leading to the discovery of two most potent inhibitors, P21 and P26, which significantly impair BxPC-3 pancreatic cancer cell survival. A series of interacting protein hits, such as GSTO1, FAM213A, RAB6A/6B/39A and USMG5, were subsequently identified by quantitative chemoproteomics studies. The main cellular target, GSTO1, was further validated as a novel pancreatic cancer therapeutic target.
收录类别	SCI ; SCIE
语种	英语
资助项目	Science and Technology Program of Guangzhou[201704030060] ; Science and Technology Program of Guangzhou[201805010007]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000457645500011
出版者	ROYAL SOC CHEMISTRY
WOS关键词	DISCOVERY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30246
专题	生命科学与技术学院_公共科研平台_组学分析平台
通讯作者	Li, Zhengqiu
作者单位	1.Jinan Univ, Sch Pharm, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China 2.MOE Peoples Republ China, Guangzhou City Key Lab Precis Chem Drug Dev, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China 3.MOE Peoples Republ China, Int Cooperat Lab Tradit Chinese Med Modernizat &, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Liu, Wenyan,Zhang, Zhang,Zhang, Zhi-Min,et al. Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer[J]. CHEMICAL COMMUNICATIONS,2019,55(11):1596-1599.
APA	Liu, Wenyan,Zhang, Zhang,Zhang, Zhi-Min,Hao, Piliang,Ding, Ke,&Li, Zhengqiu.(2019).Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer.CHEMICAL COMMUNICATIONS,55(11),1596-1599.
MLA	Liu, Wenyan,et al."Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer".CHEMICAL COMMUNICATIONS 55.11(2019):1596-1599.