Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease

doi:10.1016/j.stemcr.2016.12.007

	Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease
	Huang, Shichao 1; Mao, Jianxin 2,3; Ding, Kan 4; Zhou, Yue 2; Zeng, Xianglu 1,7; Yang, Wenjuan2,3,5 ; Wang, Peipei 3,4; Zhao, Cun2,3,5 ; Yao, Jian 3,4; Xia, Peng 6; Pei, Gang1,2,7
	2017-01-10
发表期刊	STEM CELL REPORTS (IF:5.9[JCR-2023],5.9[5-Year])
ISSN	2213-6711
卷号	8 期号:1 页码:84-94
发表状态	已发表
DOI	10.1016/j.stemcr.2016.12.007
摘要	Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration of the polysaccharides and water extract from G. lucidum promoted neural progenitor cell (NPC) proliferation to enhance neurogenesis and alleviated cognitive deficits in transgenic AD mice. G. lucidum polysaccharides (GLP) also promoted self-renewal of NPC in cell culture. Further mechanistic study revealed that GLP potentiated activation of fibroblast growth factor receptor 1 (FGFR1) and downstream extracellular signal- regulated kinase (ERK) and AKT cascades. Consistently, inhibition of FGFR1 effectively blocked the GLP-promoted NPC proliferation and activation of the downstream cascades. Our findings suggest that GLP could serve as a regenerative therapeutic agent for the treatment of cognitive decline associated with neurodegenerative diseases.
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31400690]
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000396354800008
出版者	CELL PRESS
WOS关键词	HIPPOCAMPAL NEUROGENESIS ; ADULT NEUROGENESIS ; GROWTH-FACTOR ; STEM-CELLS ; EXTRACT ; RAT ; MEDICINE ; NEURONS ; BRAIN ; BETA
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2937
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_裴钢组生命科学与技术学院_硕士生
通讯作者	Pei, Gang
作者单位	1.Tongji Univ, Shanghai Key Lab Signaling & Dis Res Lab Receptor, Sch Life Sci & Technol, Shanghai 200092, Peoples R China 2.Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 6.Shanghai Green Valley Pharmaceut Co Ltd, Shanghai 201200, Peoples R China 7.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China
推荐引用方式 GB/T 7714	Huang, Shichao,Mao, Jianxin,Ding, Kan,et al. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease[J]. STEM CELL REPORTS,2017,8(1):84-94.
APA	Huang, Shichao.,Mao, Jianxin.,Ding, Kan.,Zhou, Yue.,Zeng, Xianglu.,...&Pei, Gang.(2017).Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.STEM CELL REPORTS,8(1),84-94.
MLA	Huang, Shichao,et al."Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease".STEM CELL REPORTS 8.1(2017):84-94.