Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis

doi:10.1038/s41598-017-05359-0

	Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis
	Zhang, Shuo 1; Pan, Chenyu 1; Lv, Xiangdong 1; Wu, Wei 1; Chen, Hao 1; Wu, Wenqing 1; Wu, Hailong 1; Zhang, Lei 1; Zhao, Yun1,2
	2017-07-11
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7
发表状态	已发表
DOI	10.1038/s41598-017-05359-0
摘要	Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.
收录类别	SCI
语种	英语
资助项目	Program of Shanghai Academic/Technology Research Leader[17XD1404100]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000405172600068
出版者	NATURE PUBLISHING GROUP
WOS关键词	GERMLINE STEM-CELLS ; SELF-RENEWAL ; H2A UBIQUITYLATION ; ABDOMINAL-B ; GROUP GENES ; NICHE ; PRC2 ; DIFFERENTIATION ; ACTIVATION ; EXPRESSION
原始文献类型	Article
通讯作者	Zhao, Yun
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2896
专题	生命科学与技术学院_特聘教授组_赵允组
通讯作者	Zhao, Yun
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,Innovat Ctr Cell, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Shuo,Pan, Chenyu,Lv, Xiangdong,et al. Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis[J]. SCIENTIFIC REPORTS,2017,7.
APA	Zhang, Shuo.,Pan, Chenyu.,Lv, Xiangdong.,Wu, Wei.,Chen, Hao.,...&Zhao, Yun.(2017).Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.SCIENTIFIC REPORTS,7.
MLA	Zhang, Shuo,et al."Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis".SCIENTIFIC REPORTS 7(2017).