Identification of a hybrid myocardial zone in the mammalian heart after birth
Tian, Xueying1,2; Li, Yan1,2; He, Lingjuan1,2; Zhang, Hui2,3; Huang, Xiuzhen1,2; Liu, Qiaozhen1,2; Pu, Wenjuan1,2; Zhang, Libo1,2; Li, Yi1,2; Zhao, Huan1,2; Wang, Zhifu4,5; Zhu, Jianhong4,5; Nie, Yu6,7; Hu, Shengshou6,7; Sedmera, David8,9; Zhong, Tao P.10; Yu, Ying2,11; Zhang, Li12; Yan, Yan13; Qiao, Zengyong14; Wang, Qing-Dong15; Wu, Sean M.16; Pu, William T.17,18; Anderson, Robert H.19; Zhou, Bin1,2,3,20
AbstractNoncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
Indexed BySCI
Funding ProjectCzech Science Foundation[13-12412S] ; Czech Science Foundation[16-02972S]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000405900400004
Original Document TypeArticle
Corresponding AuthorZhou, Bin
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Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhou, Bin
Affiliation1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China
3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Neurosurg, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China
5.Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China
6.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China
7.Peking Union Med Coll, Beijing 100037, Peoples R China
8.Charles Univ Prague, Fac Med 1, Inst Anat, Prague 12800, Czech Republic
9.Czech Acad Sci, Inst Physiol, Prague 12800, Czech Republic
10.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
11.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin 300070, Peoples R China
12.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
13.Fudan Univ, Zhongshan Hosp, Cardiol Dept, Shanghai 200032, Peoples R China
14.Southern Med Univ, Dept Cardiovasc Med, Affiliated Fengxian Hosp, Shanghai 201499, Peoples R China
15.AstraZeneca, Innovat Med & Early Clin Dev Biotech Unit, Cardiovasc & Metab Dis, S-43183 Molndal, Sweden
16.Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Div Cardiovasc Med,Dept Med, Stanford, CA 94305 USA
17.Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA
18.Childrens Hosp Boston, Dept Cardiol, 300 Longwood Ave, Boston, MA 02115 USA
19.Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
20.Jinan Univ, Inst Aging & Regenerat Med, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Tian, Xueying,Li, Yan,He, Lingjuan,et al. Identification of a hybrid myocardial zone in the mammalian heart after birth[J]. NATURE COMMUNICATIONS,2017,8.
APA Tian, Xueying.,Li, Yan.,He, Lingjuan.,Zhang, Hui.,Huang, Xiuzhen.,...&Zhou, Bin.(2017).Identification of a hybrid myocardial zone in the mammalian heart after birth.NATURE COMMUNICATIONS,8.
MLA Tian, Xueying,et al."Identification of a hybrid myocardial zone in the mammalian heart after birth".NATURE COMMUNICATIONS 8(2017).
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