Identification of a hybrid myocardial zone in the mammalian heart after birth

doi:10.1038/s41467-017-00118-1

	Identification of a hybrid myocardial zone in the mammalian heart after birth
	Tian, Xueying 1,2; Li, Yan 1,2; He, Lingjuan 1,2; Zhang, Hui 2,3; Huang, Xiuzhen 1,2; Liu, Qiaozhen 1,2; Pu, Wenjuan 1,2; Zhang, Libo 1,2; Li, Yi 1,2; Zhao, Huan 1,2; Wang, Zhifu 4,5; Zhu, Jianhong 4,5; Nie, Yu 6,7; Hu, Shengshou 6,7; Sedmera, David 8,9; Zhong, Tao P.10; Yu, Ying 2,11; Zhang, Li 12; Yan, Yan 13; Qiao, Zengyong 14; Wang, Qing-Dong 15; Wu, Sean M.16; Pu, William T.17,18; Anderson, Robert H.19; Zhou, Bin1,2,3,20
	2017-07-20
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	8
发表状态	已发表
DOI	10.1038/s41467-017-00118-1
摘要	Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
收录类别	SCI
语种	英语
资助项目	Czech Science Foundation[13-12412S] ; Czech Science Foundation[16-02972S]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000405900400004
出版者	NATURE PUBLISHING GROUP
WOS关键词	LEFT-VENTRICULAR NONCOMPACTION ; LINEAGE TRACING REVEALS ; CORONARY-ARTERIES ; CARDIOMYOCYTE PROLIFERATION ; GENE-EXPRESSION ; NON-COMPACTION ; CELLS ; ANGIOGENESIS ; KNOCKOUT ; LIVER
原始文献类型	Article
通讯作者	Zhou, Bin
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2892
专题	生命科学与技术学院_特聘教授组_周斌组
通讯作者	Zhou, Bin
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Fudan Univ, Huashan Hosp, Dept Neurosurg, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China 6.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China 7.Peking Union Med Coll, Beijing 100037, Peoples R China 8.Charles Univ Prague, Fac Med 1, Inst Anat, Prague 12800, Czech Republic 9.Czech Acad Sci, Inst Physiol, Prague 12800, Czech Republic 10.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 11.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin 300070, Peoples R China 12.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China 13.Fudan Univ, Zhongshan Hosp, Cardiol Dept, Shanghai 200032, Peoples R China 14.Southern Med Univ, Dept Cardiovasc Med, Affiliated Fengxian Hosp, Shanghai 201499, Peoples R China 15.AstraZeneca, Innovat Med & Early Clin Dev Biotech Unit, Cardiovasc & Metab Dis, S-43183 Molndal, Sweden 16.Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Div Cardiovasc Med,Dept Med, Stanford, CA 94305 USA 17.Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA 18.Childrens Hosp Boston, Dept Cardiol, 300 Longwood Ave, Boston, MA 02115 USA 19.Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England 20.Jinan Univ, Inst Aging & Regenerat Med, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Tian, Xueying,Li, Yan,He, Lingjuan,et al. Identification of a hybrid myocardial zone in the mammalian heart after birth[J]. NATURE COMMUNICATIONS,2017,8.
APA	Tian, Xueying.,Li, Yan.,He, Lingjuan.,Zhang, Hui.,Huang, Xiuzhen.,...&Zhou, Bin.(2017).Identification of a hybrid myocardial zone in the mammalian heart after birth.NATURE COMMUNICATIONS,8.
MLA	Tian, Xueying,et al."Identification of a hybrid myocardial zone in the mammalian heart after birth".NATURE COMMUNICATIONS 8(2017).