Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities

doi:10.1021/acs.joc.8b02346

	Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities
	Zhang, Rui 1,2,3; Tang, Chunping 1,2,4; Liu, Hong-Chun 5; Ren, Yongmei1,2,3,6 ; Xu, Cheng-hui 5; Ke, Chang-Qiang 1,2,4; Yao, Sheng 1,2,4; Huang, Xun 5; Ye, Yang1,2,3,4,6
	2018-11-16
发表期刊	JOURNAL OF ORGANIC CHEMISTRY (IF:3.3[JCR-2023],3.2[5-Year])
ISSN	0022-3263
卷号	83 期号:22 页码:14175-14180
发表状态	已发表
DOI	10.1021/acs.joc.8b02346
摘要	Ainsliatriolides A (1) and B (2), two guaianolide sesquiterpenoid trimers possessing an unprecedented skeleton, were isolated from Ainsliaea fragrans. Their structures were elucidated through extensive analysis of spectroscopic data and confirmed by single-crystal X-ray diffraction experiment. Ainsliatriolides A and B are first examples of compound trimerized from guaianolide sesquiterpenoids through two different C-C linkages (type A, 4-2'/15-14'; type B, 15'-15 ''). Ainsliatriolide A displayed potent cytotoxicity with an averaged IC50 value of 1.17 mu M against four cancer cells.
收录类别	EI ; SCIE ; SCI ; IC
语种	英语
资助项目	International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000451101000056
出版者	AMER CHEMICAL SOC
EI入藏号	20184606058681
EI主题词	Oligomers ; Single crystals ; Spectroscopic analysis
WOS关键词	BIOMIMETIC SYNTHESES ; LACTONES
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28722
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Huang, Xun; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Rui,Tang, Chunping,Liu, Hong-Chun,et al. Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(22):14175-14180.
APA	Zhang, Rui.,Tang, Chunping.,Liu, Hong-Chun.,Ren, Yongmei.,Xu, Cheng-hui.,...&Ye, Yang.(2018).Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities.JOURNAL OF ORGANIC CHEMISTRY,83(22),14175-14180.
MLA	Zhang, Rui,et al."Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities".JOURNAL OF ORGANIC CHEMISTRY 83.22(2018):14175-14180.