Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling

doi:10.1681/ASN.2017121275

	Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling
	Weng, Zhuangfeng2,3 ; Shang, Yuan 1,4; Ji, Zeyang 4; Ye, Fei 4,5; Lin, Lin 2; Zhang, Rongguang2,3 ; Zhu, Jinwei 2
	2018-09
发表期刊	JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (IF:10.3[JCR-2023],10.5[5-Year])
ISSN	1046-6673
卷号	29 期号:9 页码:2362-2371
发表状态	已发表
DOI	10.1681/ASN.2017121275
摘要	Background The slit diaphragm is a specialized adhesion junction between opposing podocytes, establishing the final filtration barrier that prevents passage of proteins from the capillary lumen into the urinary space. Nephrin, the key structural and signaling adhesion molecule expressed in the slit diaphragm, contains an evolutionally conserved, atypical PDZ-binding motif (PBM) reported to bind to a variety of proteins in the slit diaphragm. Several mutations in NPHS1 (the gene encoding nephrin) that result in nephrin lacking an intact PBM are associated with glomerular diseases. However, the molecular basis of nephrin-PBM-mediated protein complexes is still unclear.
收录类别	SCI ; SCIE
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB08030104]
WOS研究方向	Urology & Nephrology
WOS类目	Urology & Nephrology
WOS记录号	WOS:000449014200012
出版者	AMER SOC NEPHROLOGY
WOS关键词	CONGENITAL NEPHROTIC SYNDROME ; FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; PROTEINS ; MUTATIONS ; PODOCYTES ; COMPLEX ; FILTRATION ; MEMBRANE ; ADHESION ; DISEASE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28286
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_张荣光组
通讯作者	Zhang, Rongguang; Zhu, Jinwei
作者单位	1.Univ Arizona, Ctr Biomed Informat & Biostat, Tucson, AZ USA 2.Univ Chinese Acad Sci, Chinese Acad Sci, Ctr Excellence Mol Cell Sci,Shanghai Sci Res Ctr, State Key Lab Mol Biol,Shanghai Inst Biochem & Ce, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Life Sci, Kowloon, Hong Kong, Peoples R China 5.Hong Kong Univ Sci & Technol, Ctr Syst Biol & Human Hlth, Kowloon, Hong Kong, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Weng, Zhuangfeng,Shang, Yuan,Ji, Zeyang,et al. Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2018,29(9):2362-2371.
APA	Weng, Zhuangfeng.,Shang, Yuan.,Ji, Zeyang.,Ye, Fei.,Lin, Lin.,...&Zhu, Jinwei.(2018).Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,29(9),2362-2371.
MLA	Weng, Zhuangfeng,et al."Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling".JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 29.9(2018):2362-2371.