Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes

doi:10.1039/c7ob01271c

	Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes
	Fan, Zhoulong 1,2,3; Lu, Heng4 ; Li, Wei 1,2; Geng, Kaijun 1,2,3; Zhang, Ao1,2,3,4
	2017-07-21
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY (IF:2.9[JCR-2023],2.8[5-Year])
ISSN	1477-0520
卷号	15 期号:27 页码:5701-5708
发表状态	已发表
DOI	10.1039/c7ob01271c
摘要	A switchable synthesis of N-substituted indole derivatives from phenidones via rhodium-catalyzed redox-neutral C-H activation has been achieved. In this protocol, we firstly disclosed that the reactivity of Rh(III) catalysis could be enhanced through employing palladium acetate as an additive. Some representative features include external oxidant-free, applicable to terminal alkynes, short reaction time and operational simplicity. The utility of this method is further showcased by the economical synthesis of potent anticancer PARP-1 inhibitors.
收录类别	SCI ; IC ; CCR ; EI
语种	英语
资助项目	CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YKF-08] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YZZ-06]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000405482000008
出版者	ROYAL SOC CHEMISTRY
EI入藏号	20172903959254
EI主题词	Activation analysis ; Catalysis ; Hydrocarbons ; Organometallics
EI分类号	Precious Metals:547.1 ; Chemical Reactions:802.2 ; Organic Compounds:804.1
WOS关键词	C-H ACTIVATION ; N-N BOND ; OXIDIZING DIRECTING GROUP ; OXYGEN-ATOM TRANSFER ; EFFICIENT SYNTHESIS ; REGIOSELECTIVE SYNTHESIS ; INTERNAL ALKYNES ; RHODIUM(III)-CATALYZED SYNTHESIS ; SUBSTITUTED INDOLES ; DIAZO-COMPOUNDS
原始文献类型	Article
通讯作者	Zhang, Ao
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2796
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_张翱组生命科学与技术学院_博士生
通讯作者	Zhang, Ao
作者单位	1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Shanghai 201210, Peoples R China
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Fan, Zhoulong,Lu, Heng,Li, Wei,et al. Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(27):5701-5708.
APA	Fan, Zhoulong,Lu, Heng,Li, Wei,Geng, Kaijun,&Zhang, Ao.(2017).Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes.ORGANIC & BIOMOLECULAR CHEMISTRY,15(27),5701-5708.
MLA	Fan, Zhoulong,et al."Rhodium-catalyzed redox-neutral coupling of phenidones with alkynes".ORGANIC & BIOMOLECULAR CHEMISTRY 15.27(2017):5701-5708.