Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component
Wang, Jialing1,2; Yuan, Shuai1; Zhu, Dongjie1; Tang, Hao3; Wang, Nan1,2; Chen, Wenyuan3; Gao, Qiang1,4; Li, Yuhua5; Wang, Junzhi5; Liu, Hongrong3
2018-09-10
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号9
发表状态已发表
DOI10.1038/s41467-018-06078-4
摘要Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the alpha-herpesvirinae subfamily that together with the beta- and gamma-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 angstrom using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify alpha-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.
收录类别SCI ; SCIE
语种英语
资助项目Technology Planning Project of Hunan Province[2017RS3033]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000444078300011
出版者NATURE PUBLISHING GROUP
WOS关键词SARCOMA-ASSOCIATED HERPESVIRUS ; EM STRUCTURE DETERMINATION ; PARTICLE CRYO-EM ; MUTAGENESIS REVEAL ; TEGUMENT PROTEIN ; BINDING ; DNA ; ALPHAHERPESVIRUSES ; RECONSTRUCTIONS ; RECONSTITUTION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27777
专题免疫化学研究所_特聘教授组_饶子和组
通讯作者Liu, Hongrong; Zhang, Xinzheng; Rao, Zihe; Wang, Xiangxi
作者单位1.Chinese Acad Sci, Inst Biophys, Natl Lab Macromol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Synerget Innovat Ctr Quantum Effects & Applicat, Coll Phys & Informat Sci,Minist Educ, Changsha 410008, Hunan, Peoples R China
4.Sinovac Biotech Co Ltd, Beijing 100085, Peoples R China
5.Natl Inst Food & Drug Control, 2 Tiantanxili, Beijing 100050, Peoples R China
6.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
7.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300353, Peoples R China
8.Tsinghua Univ, Struct Biol Lab, Beijing 100084, Peoples R China
通讯作者单位免疫化学研究所
推荐引用方式
GB/T 7714
Wang, Jialing,Yuan, Shuai,Zhu, Dongjie,et al. Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component[J]. NATURE COMMUNICATIONS,2018,9.
APA Wang, Jialing.,Yuan, Shuai.,Zhu, Dongjie.,Tang, Hao.,Wang, Nan.,...&Wang, Xiangxi.(2018).Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.NATURE COMMUNICATIONS,9.
MLA Wang, Jialing,et al."Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component".NATURE COMMUNICATIONS 9(2018).
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