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Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component | |
Wang, Jialing1,2; Yuan, Shuai1; Zhu, Dongjie1; Tang, Hao3; Wang, Nan1,2; Chen, Wenyuan3; Gao, Qiang1,4; Li, Yuhua5; Wang, Junzhi5; Liu, Hongrong3 | |
2018-09-10 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 9 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-018-06078-4 |
摘要 | Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the alpha-herpesvirinae subfamily that together with the beta- and gamma-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 angstrom using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify alpha-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability. |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | Technology Planning Project of Hunan Province[2017RS3033] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000444078300011 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | SARCOMA-ASSOCIATED HERPESVIRUS ; EM STRUCTURE DETERMINATION ; PARTICLE CRYO-EM ; MUTAGENESIS REVEAL ; TEGUMENT PROTEIN ; BINDING ; DNA ; ALPHAHERPESVIRUSES ; RECONSTRUCTIONS ; RECONSTITUTION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27777 |
专题 | 免疫化学研究所_特聘教授组_饶子和组 |
通讯作者 | Liu, Hongrong; Zhang, Xinzheng; Rao, Zihe; Wang, Xiangxi |
作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Macromol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Synerget Innovat Ctr Quantum Effects & Applicat, Coll Phys & Informat Sci,Minist Educ, Changsha 410008, Hunan, Peoples R China 4.Sinovac Biotech Co Ltd, Beijing 100085, Peoples R China 5.Natl Inst Food & Drug Control, 2 Tiantanxili, Beijing 100050, Peoples R China 6.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 7.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300353, Peoples R China 8.Tsinghua Univ, Struct Biol Lab, Beijing 100084, Peoples R China |
通讯作者单位 | 免疫化学研究所 |
推荐引用方式 GB/T 7714 | Wang, Jialing,Yuan, Shuai,Zhu, Dongjie,et al. Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Wang, Jialing.,Yuan, Shuai.,Zhu, Dongjie.,Tang, Hao.,Wang, Nan.,...&Wang, Xiangxi.(2018).Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.NATURE COMMUNICATIONS,9. |
MLA | Wang, Jialing,et al."Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component".NATURE COMMUNICATIONS 9(2018). |
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