Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles

doi:10.1016/j.jes.2017.10.014

	Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles
	Wang, Xue 1,4,5; Cheng, Wenge2,6,7 ; Yang, Qiuyuan 1; Niu, Hongyun 1; Liu, Qian 1; Liu, Yun 5; Gao, Ming 1; Xu, Ming 1,3; Xu, An 5; Liu, Sijin 1,3; Huang, Xiaoyu6,7 ; Du, Yuguo 1
	2018-07
发表期刊	JOURNAL OF ENVIRONMENTAL SCIENCES (IF:5.9[JCR-2023],5.6[5-Year])
ISSN	1001-0742
卷号	69 页码:217-226
发表状态	已发表
DOI	10.1016/j.jes.2017.10.014
摘要	As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles, trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles (PTFE-PMMA NPs) were synthesized with various fluorine contents (PTFE-PMMA-1 NPs 12.0 wt.%, PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine (F) contents and F-containing side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose (50 mu g/mL) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species (ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials (ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. (c) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
关键词	Fluorinated nanoparticles Polymer Cytotoxicity Oxidative stress Health risk
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Natural Science Foundation of China[21407169]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000439688100024
出版者	SCIENCE PRESS
WOS关键词	F-19 MAGNETIC-RESONANCE ; GRAPHENE OXIDE ; PERFLUOROOCTANE SULFONATE ; IN-VITRO ; CELLS ; TOXICITY ; DAMAGE ; LIVER ; METABOLISM ; MECHANISMS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27401
专题	物质科学与技术学院物质科学与技术学院_特聘教授组_黄晓宇组物质科学与技术学院_硕士生
通讯作者	Xu, Ming; Huang, Xiaoyu
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China 5.Chinese Acad Sci & Anhui Prov, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Polymer Mat, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xue,Cheng, Wenge,Yang, Qiuyuan,et al. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2018,69:217-226.
APA	Wang, Xue.,Cheng, Wenge.,Yang, Qiuyuan.,Niu, Hongyun.,Liu, Qian.,...&Du, Yuguo.(2018).Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.JOURNAL OF ENVIRONMENTAL SCIENCES,69,217-226.
MLA	Wang, Xue,et al."Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles".JOURNAL OF ENVIRONMENTAL SCIENCES 69(2018):217-226.