上海科技大学知识管理系统

Norditerpenoid dilactones with various modifications on the A-ring are common in nature, which exhibit a variety of biological and pharmaceutical activities. In this work, 31 norditerpenoid dilactone derivatives with functionalization on the A- and C-rings were prepared by employed 3 beta-hydroxydilactone as a common precursor. Cytotoxic evaluation showed that norditerpenoid dilactones bearing 3 beta-OH and 1,2-beta-epoxide or 2,3-beta-epoxide displayed promising inhibitory activities against tumor cell lines (IC50=1.0-6.5 mu M).