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| Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri | |
| 2022-12-01 | |
| Source Publication | MOLECULES
 |
| EISSN | 1420-3049 |
| Volume | 27Issue:23 |
| Status | 已发表 |
| DOI | 10.3390/molecules27238197 |
| Abstract | Eleven highly oxidized withanolides, chantriolides F-P (1-11), together with six known analogues (12-17), were isolated from the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were further confirmed by experimental ECD data and single crystal X-ray diffraction analysis. The structures of compounds 5-8 contained a chlorine atom substituted at C-3. Compounds 1 and 12 are a pair of epimers isomerized at C-24 and C-25, while compounds 9 and 16 are isomerized at C-1, C-7, C-24, and C-25. Next, the hepatoprotective effect of all the isolates was evaluated on tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes. Compounds 5-11 and 16 significantly enhanced cell viability. Compound 8 decreased reactive oxygen species accumulation and increased glutathione level in t-BHP injured AML12 hepatocytes through promoting nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). |
| Keyword | Tacca chantrieri structural elucidation withanolides chantriolides F-P hepatoprotective effect |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China["21920102003","81903485","81872754"] ; University of Macau[MYRG2020-00091-ICMS] ; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau[QRCM-IRG2022-014] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS ID | WOS:000897346500001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/268666 |
| Collection | 生命科学与技术学院_特聘教授组_叶阳组 |
| Corresponding Author | Tang, Chunping; Ye, Yang |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Xishuangbanna Hosp Tradit Dai Med, Xishuangbanna Res Inst Nationality Med, 8 Zhuangdong Western Rd Xishuangbanna Tourism & R, Xishuangbanna 666100, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yang, Yue,Zhou, Fei,Wang, Min,et al. Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri[J]. MOLECULES,2022,27(23). |
| APA | Yang, Yue.,Zhou, Fei.,Wang, Min.,Turanazarov, Mukhammadrizo.,Wang, Xiao-Rong.,...&Ye, Yang.(2022).Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri.MOLECULES,27(23). |
| MLA | Yang, Yue,et al."Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri".MOLECULES 27.23(2022). |
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