Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri
2022-12-01
Source PublicationMOLECULES
EISSN1420-3049
Volume27Issue:23
Status已发表
DOI10.3390/molecules27238197
AbstractEleven highly oxidized withanolides, chantriolides F-P (1-11), together with six known analogues (12-17), were isolated from the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were further confirmed by experimental ECD data and single crystal X-ray diffraction analysis. The structures of compounds 5-8 contained a chlorine atom substituted at C-3. Compounds 1 and 12 are a pair of epimers isomerized at C-24 and C-25, while compounds 9 and 16 are isomerized at C-1, C-7, C-24, and C-25. Next, the hepatoprotective effect of all the isolates was evaluated on tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes. Compounds 5-11 and 16 significantly enhanced cell viability. Compound 8 decreased reactive oxygen species accumulation and increased glutathione level in t-BHP injured AML12 hepatocytes through promoting nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).
KeywordTacca chantrieri structural elucidation withanolides chantriolides F-P hepatoprotective effect
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Indexed BySCI
Language英语
Funding ProjectNational Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China["21920102003","81903485","81872754"] ; University of Macau[MYRG2020-00091-ICMS] ; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau[QRCM-IRG2022-014]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000897346500001
PublisherMDPI
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Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/268666
Collection生命科学与技术学院_特聘教授组_叶阳组
Corresponding AuthorTang, Chunping; Ye, Yang
Affiliation
1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Xishuangbanna Hosp Tradit Dai Med, Xishuangbanna Res Inst Nationality Med, 8 Zhuangdong Western Rd Xishuangbanna Tourism & R, Xishuangbanna 666100, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Yang, Yue,Zhou, Fei,Wang, Min,et al. Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri[J]. MOLECULES,2022,27(23).
APA Yang, Yue.,Zhou, Fei.,Wang, Min.,Turanazarov, Mukhammadrizo.,Wang, Xiao-Rong.,...&Ye, Yang.(2022).Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri.MOLECULES,27(23).
MLA Yang, Yue,et al."Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri".MOLECULES 27.23(2022).
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