Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri

doi:10.3390/molecules27238197

	Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri
	Yang, Yue 1,2; Zhou, Fei 3; Wang, Min 2,4; Turanazarov, Mukhammadrizo 2,4; Wang, Xiao-Rong 5; Ke, Changqiang 1,2; Yao, Sheng 1,2; Lin, Ligen 3; Tang, Chunping 1,2; Ye, Yang1,2,4,6
	2022-12-01
发表期刊	MOLECULES (IF:4.2[JCR-2023],4.6[5-Year])
EISSN	1420-3049
卷号	27 期号:23
发表状态	已发表
DOI	10.3390/molecules27238197
摘要	Eleven highly oxidized withanolides, chantriolides F-P (1-11), together with six known analogues (12-17), were isolated from the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis and comparison with published NMR data, and their absolute configurations were further confirmed by experimental ECD data and single crystal X-ray diffraction analysis. The structures of compounds 5-8 contained a chlorine atom substituted at C-3. Compounds 1 and 12 are a pair of epimers isomerized at C-24 and C-25, while compounds 9 and 16 are isomerized at C-1, C-7, C-24, and C-25. Next, the hepatoprotective effect of all the isolates was evaluated on tert-butyl hydroperoxide (t-BHP)-injured AML12 hepatocytes. Compounds 5-11 and 16 significantly enhanced cell viability. Compound 8 decreased reactive oxygen species accumulation and increased glutathione level in t-BHP injured AML12 hepatocytes through promoting nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).
关键词	Tacca chantrieri structural elucidation withanolides chantriolides F-P hepatoprotective effect
URL	查看原文
收录类别	SCI
语种	英语
资助项目	National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China["21920102003","81903485","81872754"] ; University of Macau[MYRG2020-00091-ICMS] ; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau[QRCM-IRG2022-014]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000897346500001
出版者	MDPI
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/268666
专题	生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Tang, Chunping; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Xishuangbanna Hosp Tradit Dai Med, Xishuangbanna Res Inst Nationality Med, 8 Zhuangdong Western Rd Xishuangbanna Tourism & R, Xishuangbanna 666100, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Yue,Zhou, Fei,Wang, Min,et al. Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri[J]. MOLECULES,2022,27(23).
APA	Yang, Yue.,Zhou, Fei.,Wang, Min.,Turanazarov, Mukhammadrizo.,Wang, Xiao-Rong.,...&Ye, Yang.(2022).Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri.MOLECULES,27(23).
MLA	Yang, Yue,et al."Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri".MOLECULES 27.23(2022).