Establishment of SIAISi021-A, an induced pluripotent stem cell (iPSC) line from a 71-year-old Chinese Han male with Alzheimer?s Disease (AD) having two copies of APOE4/4 allele

doi:10.1016/j.scr.2022.102866

	Establishment of SIAISi021-A, an induced pluripotent stem cell (iPSC) line from a 71-year-old Chinese Han male with Alzheimer?s Disease (AD) having two copies of APOE4/4 allele
	Ding, Yanfei 1,2,3; Chen, Haijuan 1,2,3; Zhao, Jian4,5 ; Wang, Ying4,5 ; Deng, Yulei 1,2,3
	2022-08-01
发表期刊	STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN	1873-5061
EISSN	1876-7753
卷号	63
发表状态	已发表
DOI	10.1016/j.scr.2022.102866
摘要	A 71-year-old Han male from China contributed peripheral blood mononuclear cells (PBMCs). Non-integrative Sendai viral vectors containing reprogramming factors OCT4, KLF4, SOX2 and C-MYC were used to reprogram PBMCs. Pluripotency makers confirmed the pluripotency of transgene-free induced pluripotent stem cell (iPSC). The ability of iPSC to spontaneously differentiate three germ layers in vitro confirmed the pluripotency of iPSC. The iPSC line displayed a normal karyotype. The newly generated human iPSC SIAISi021-A can be used for studying further disease mechanisms of Alzheimer's Disease (AD).
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82171400] ; Natural Science Foundation of Shanghai[19ZR1432500]
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology
WOS记录号	WOS:000885889600009
出版者	ELSEVIER
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/266595
专题	生命科学与技术学院免疫化学研究所_PI研究组_赵简组
通讯作者	Wang, Ying; Deng, Yulei
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Luwan Branch,Sch Med, Shanghai, Peoples R China 4.ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Lab Regenerat Med & Neural Repair, Shanghai, Peoples R China 5.ShanghaiTech, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所; 生命科学与技术学院
推荐引用方式 GB/T 7714	Ding, Yanfei,Chen, Haijuan,Zhao, Jian,et al. Establishment of SIAISi021-A, an induced pluripotent stem cell (iPSC) line from a 71-year-old Chinese Han male with Alzheimer?s Disease (AD) having two copies of APOE4/4 allele[J]. STEM CELL RESEARCH,2022,63.
APA	Ding, Yanfei,Chen, Haijuan,Zhao, Jian,Wang, Ying,&Deng, Yulei.(2022).Establishment of SIAISi021-A, an induced pluripotent stem cell (iPSC) line from a 71-year-old Chinese Han male with Alzheimer?s Disease (AD) having two copies of APOE4/4 allele.STEM CELL RESEARCH,63.
MLA	Ding, Yanfei,et al."Establishment of SIAISi021-A, an induced pluripotent stem cell (iPSC) line from a 71-year-old Chinese Han male with Alzheimer?s Disease (AD) having two copies of APOE4/4 allele".STEM CELL RESEARCH 63(2022).