Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging

doi:10.3389/fnins.2022.1015843

	Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging
	Hsieh, Bao-Yu 1,2; Kao, Yu-Chieh Jill 3; Zhou, Ning4 ; Lin, Yi-Pei 5; Mei, Yu-Ying 6; Chu, Sung-Yu 2; Wu, Dong-Chuan 6
	2022-11-16
发表期刊	FRONTIERS IN NEUROSCIENCE (IF:3.2[JCR-2023],4.3[5-Year])
EISSN	1662-453X
卷号	16
发表状态	已发表
DOI	10.3389/fnins.2022.1015843
摘要	The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related to pathophysiological consequences in numerous neurovascular conditions, including ischemia, traumatic brain injury, cerebral hemorrhage, and migraine. Monitoring of the hemodynamic responses of cerebral penetrating vessels during CSD is motivated to understand the mechanism of CSD and related neurological disorders. Six SD rats were used, and craniotomy surgery was performed before imaging. CSDs were induced by topical KCl application. Ultrasound dynamic ultrafast Doppler was used to access hemodynamic changes, including cerebral blood volume (CBV) and flow velocity during CSD, and further analyzed those in a single penetrating arteriole or venule. The CSD-induced hemodynamic changes with typical duration and propagation speed were detected by ultrafast Doppler in the cerebral cortex ipsilateral to the induction site. The hemodynamics typically showed triphasic changes, including initial hypoperfusion and prominent hyperperfusion peak, followed by a long-period depression in CBV. Moreover, different hemodynamics between individual penetrating arterioles and venules were proposed by quantification of CBV and flow velocity. The negative correlation between the basal CBV and CSD-induced change was also reported in penetrating vessels. These results indicate specific vascular dynamics of cerebral penetrating vessels and possibly different contributions of penetrating arterioles and venules to the CSD-related pathological vascular consequences. We proposed using ultrasound dynamic ultrafast Doppler imaging to investigate CSD-induced cerebral vascular responses. With this imaging platform, it has the potential to monitor the hemodynamics of cortical penetrating vessels during brain injuries to understand the mechanism of CSD in advance.
关键词	cortical spreading depolarization (CSD) cortical penetrating vessels cerebral blood volume (CBV) flow velocity ultrasound dynamic ultrafast Doppler
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收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000892704700001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/258941
专题	iHuman研究所_PI研究组_周宁组
通讯作者	Hsieh, Bao-Yu
作者单位	1.Chang Gung Univ, Coll Med, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan 2.Chang Gung Mem Hosp Linkou, Dept Med Imaging & Intervent, Taoyuan, Taiwan 3.Natl Yang Ming Chiao Tung Univ, Coll Biomed Sci & Engn, Dept Biomed Imaging & Radiol Sci, Taipei, Taiwan 4.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 5.China Med Univ, Coll Med, Dept Biomed Imaging & Radiol Sci, Taichung, Taiwan 6.China Med Univ, Grad Inst Biomed Sci, Coll Med, Taichung, Taiwan
推荐引用方式 GB/T 7714	Hsieh, Bao-Yu,Kao, Yu-Chieh Jill,Zhou, Ning,et al. Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging[J]. FRONTIERS IN NEUROSCIENCE,2022,16.
APA	Hsieh, Bao-Yu.,Kao, Yu-Chieh Jill.,Zhou, Ning.,Lin, Yi-Pei.,Mei, Yu-Ying.,...&Wu, Dong-Chuan.(2022).Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging.FRONTIERS IN NEUROSCIENCE,16.
MLA	Hsieh, Bao-Yu,et al."Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging".FRONTIERS IN NEUROSCIENCE 16(2022).