Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by beta-Glucan Treatment in Trained Immunity

doi:10.1007/s10753-022-01767-1

	Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by beta-Glucan Treatment in Trained Immunity
	Li, Feiyang; Sun, Jianlong
	2022-11
发表期刊	INFLAMMATION (IF:4.5[JCR-2023],4.6[5-Year])
ISSN	0360-3997
EISSN	1573-2576
发表状态	已发表
DOI	10.1007/s10753-022-01767-1
摘要	Agonists of trained immunity induce epigenetic changes in hematopoietic stem and progenitor cells (HSPCs) to generate long-lasting immune protection. Although trained HSPCs generate myeloid cells with increased responsiveness to secondary challenges, whether their differentiation kinetics is affected by prior exposure to inducers of trained immunity remains elusive. Here, we used lineage tracing to examine the cell fates of endothelial protein C receptor-positive hematopoietic stem cells (EPCR+ HSCs) and fms-like tyrosine kinase 3-positive multipotent progenitor cells (Flt3(+) MPPs) in beta-glucan-induced trained immunity. We found that although beta-glucan triggered the expected expansion of myeloid progenitors, the differentiation behaviors of EPCR+ HSCs and Flt3(+) MPPs in multiple cycles of hematopoietic regeneration were hardly affected. Thus, our results rule out changed kinetics in cell differentiation by EPCR+ HSC and Flt3(+) MPP as the cause of enhanced myelopoiesis upon secondary immune challenges.
关键词	Trained immunity Hematopoietic stem and progenitor cells beta-glucan Differentiation Lineage tracing
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	National Key R&D Program of China[2020YFA0710801] ; National Natural Science Foundation of China[81970102]
WOS研究方向	Cell Biology ; Immunology
WOS类目	Cell Biology ; Immunology
WOS记录号	WOS:000886423500001
出版者	SPRINGER/PLENUM PUBLISHERS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/251696
专题	生命科学与技术学院_PI研究组_孙建龙组
通讯作者	Sun, Jianlong
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Feiyang,Sun, Jianlong. Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by beta-Glucan Treatment in Trained Immunity[J]. INFLAMMATION,2022.
APA	Li, Feiyang,&Sun, Jianlong.(2022).Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by beta-Glucan Treatment in Trained Immunity.INFLAMMATION.
MLA	Li, Feiyang,et al."Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by beta-Glucan Treatment in Trained Immunity".INFLAMMATION (2022).