Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes

doi:10.1186/s12964-022-00985-2

	Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes
	Liu, Zhaoyun 1; Guo, Yixuan 1; Huang, Lei 1; Jia, Yue 1; Liu, Hui 1; Peng, Fengping 1; Duan, Lixiang 2; Zhang, Hongkai3,4 ; Fu, Rong 1
	2022-10-27
发表期刊	CELL COMMUNICATION AND SIGNALING
EISSN	1478-811X
卷号	20 期号:1
发表状态	已发表
DOI	10.1186/s12964-022-00985-2
摘要	Background: Myelodysplastic syndrome (MDS) is a clonal disease of hematopoietic cells, characterized by hematopoietic cell hematopoiesis and a high risk of transformation into acute myeloid leukemia (AML). Although the underlying mechanism is unclear, MDS is often associated with immune system disorders, especially cellular immune abnormalities. We analyzed the number of lymphocyte subsets by flow cytometry assay and explored the alteration of lymphocyte subsets in MDS. Methods: Healthy controls, inpatients with primary MDS and patients with AML diagnosed from January 2017 to July 2021 were included. Flow cytometry assays were used to study lymphocyte subsets obtained from the bone marrow of the participants as well as changes in natural killer (NK) cell function. One-way analysis of variance and Student’s t-test were used to analyze the data. Results: We found a reduction in the number and function of NK cells in patients with MDS. By further measuring the activating and inhibitory receptors on the surface of NK cells, we found that the T cell immunoglobulin and ITIM domain (TIGIT) was the highest expressed marker on NK cells. Additionally, the expression of CD155, which is the ligand of TIGIT, was significantly higher than expressions of CD112 and CD113 on bone marrow mesenchymal stem cells (BMSCs). Conclusions: The co-culture results of BMSCs and NK cells demonstrated that BMSCs regulate NK cells through the TIGIT/CD155 interaction, indicating that NK cells play a vital role in MDS progression. BMSCs regulate the function of NK cells via TIGIT/CD155.
关键词	Bone marrow mesenchymal stem cells Immune system Myelodysplastic syndrome Natural killer cells T cell immunoglobulin and ITIM domain
URL	查看原文
收录类别	SCIE
语种	英语
Scopus 记录号	2-s2.0-85140859785
来源库	Scopus
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/243356
专题	免疫化学研究所_特聘教授组_张宏恺组
通讯作者	Fu, Rong
作者单位	1.Department of Hematology,Tianjin Medical University General Hospital,Tianjin,China 2.Yuncheng Central Hospital,Yuncheng,Shanxi,China 3.Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai,201210,China 4.State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences,Nankai University,Tianjin,94 Weijin Road,300071,China
推荐引用方式 GB/T 7714	Liu, Zhaoyun,Guo, Yixuan,Huang, Lei,et al. Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes[J]. CELL COMMUNICATION AND SIGNALING,2022,20(1).
APA	Liu, Zhaoyun.,Guo, Yixuan.,Huang, Lei.,Jia, Yue.,Liu, Hui.,...&Fu, Rong.(2022).Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes.CELL COMMUNICATION AND SIGNALING,20(1).
MLA	Liu, Zhaoyun,et al."Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes".CELL COMMUNICATION AND SIGNALING 20.1(2022).