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| Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling | |
Ai, Jingwen1,2; Guo, Jingxin1,2; Zhang, Haocheng1,2; Zhang, Yi1,2; Yang, Haochen3,4; Lin, Ke1,2; Song, Jieyu1,2; Fu, Zhangfan1,2; Fan, Mingxiang5; Zhang, Qiran1,2; Wang, Hongyu1,2; Zhao, Yuanhan1,2; He, Zhangyufan1,2; Cui, An1,2; Zhou, Yang1,2; Wu, Jing1,2; Zhou, Mingzhe1,2; Yuan, Guanmin1,2; Kang, Boxi6; Zhao, Ning6; Xu, Yuanyuan1,2; Zhu, Mengqi1,2; Wang, Youhong1,2; Zhang, Zemin7; Jiang, Ning1,2,8; Qiu, Chao1,2,9; Xu, Chenqi3,10,11  ; Zhang, Wenhong1,2,12,13
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| 2022-10-21 | |
| 发表期刊 | CELL DISCOVERY (IF:13.0[JCR-2023],14.8[5-Year]) |
| ISSN | 2056-5968 |
| EISSN | 2056-5968 |
| 卷号 | 8期号:1 |
| 发表状态 | 已发表 |
| DOI | 10.1038/s41421-022-00480-5 |
| 摘要 | SARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however, its cellular mechanisms remain elusive. Here, we investigated the durability of antibody responses and single-cell immune profiles following booster dose immunization, longitudinally over 6 months, in recipients of a homologous BBIBP-CorV/BBIBP-CorV or a heterologous BBIBP-CorV/ZF2001 regimen. The production of neutralizing antibodies was dramatically enhanced by both booster regimens, and the antibodies could last at least six months. The heterologous booster induced a faster and more robust plasmablast response, characterized by activation of plasma cells than the homologous booster. The response was attributed to recall of memory B cells and the de novo activation of B cells. Expanded B cell clones upon booster dose vaccination could persist for months, and their B cell receptors displayed accumulated mutations. The production of antibody was positively correlated with antigen presentation by conventional dendritic cells (cDCs), which provides support for B cell maturation through activation and development of follicular helper T (Tfh) cells. The proper activation of cDC/Tfh/B cells was likely fueled by active energy metabolism, and glutaminolysis might also play a general role in promoting humoral immunity. Our study unveils the cellular mechanisms of booster-induced memory/adaptive humoral immunity and suggests potential strategies to optimize vaccine efficacy and durability in future iterations. |
| URL | 查看原文 |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| WOS记录号 | WOS:000871042300001 |
| 出版者 | SPRINGERNATURE |
| 原始文献类型 | Article |
| Scopus 记录号 | 2-s2.0-85140463287 |
| 来源库 | Scopus |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/243348 |
| 专题 | 生命科学与技术学院_特聘教授组_许琛琦组 |
| 作者单位 | 1.National Medical Center for Infectious Diseases,Huashan Hospital,Fudan University,Shanghai,China 2.Department of Infectious Diseases,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response,Huashan Hospital,Fudan University,Shanghai,China 3.State Key Laboratory of Molecular Biology,Shanghai Key Laboratory of Molecular Andrology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai,China 4.University of Chinese Academy of Sciences,Beijing,China 5.Department of Urology,Tongji Hospital,School of Medicine,Tongji University,Shanghai,China 6.Analytical Biosciences Limited,Beijing,China 7.Biomedical Pioneering Innovation Center (BIOPIC),School of Life Sciences,Peking University,Beijing,China 8.State Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai,China 9.Institutes of Biomedical Sciences,Fudan University,Shanghai,China 10.School of Life Science and Technology,ShanghaiTech University,Shanghai,China 11.Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang,China 12.National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai,China 13.Huashen Institute of Microbes and Infections,Shanghai,China |
| 推荐引用方式 GB/T 7714 | Ai, Jingwen,Guo, Jingxin,Zhang, Haocheng,et al. Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling[J]. CELL DISCOVERY,2022,8(1). |
| APA | Ai, Jingwen.,Guo, Jingxin.,Zhang, Haocheng.,Zhang, Yi.,Yang, Haochen.,...&Zhang, Wenhong.(2022).Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling.CELL DISCOVERY,8(1). |
| MLA | Ai, Jingwen,et al."Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling".CELL DISCOVERY 8.1(2022). |
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