The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes

doi:10.1038/s42003-022-03377-x

	The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
	Huo, Yinbo1,2,3 ; Sun, Weiping 2,4; Shi, Tiezhu 5; Gao, Song 6,7; Zhuang, Min1
	2022-05-06
发表期刊	COMMUNICATIONS BIOLOGY (IF:5.2[JCR-2023],5.6[5-Year])
ISSN	2399-3642
EISSN	2399-3642
卷号	5 期号:1 页码:423
发表状态	已发表
DOI	10.1038/s42003-022-03377-x
摘要	Mitochondria and peroxisomes are two types of functionally close-related organelles, and both play essential roles in lipid and ROS metabolism. However, how they physically interact with each other is not well understood. In this study, we apply the proximity labeling method with peroxisomal proteins and report that mitochondrial protein mitofusins (MFNs) are in proximity to peroxisomes. Overexpression of MFNs induces not only the mitochondria clustering but also the co-clustering of peroxisomes. We also report the enrichment of MFNs at the mitochondria-peroxisome interface. Induced mitofusin expression gives rise to more mitochondria-peroxisome contacting sites. Furthermore, the tethering of peroxisomes to mitochondria can be inhibited by the expression of a truncated MFN2, which lacks the transmembrane region. Collectively, our study suggests MFNs as regulators for mitochondria-peroxisome contacts. Our findings are essential for future studies of inter-organelle metabolism regulation and signaling, and may help understand the pathogenesis of mitofusin dysfunction-related disease. The MFN1 and MFN2 mitofusin proteins localize to the outer mitochondrial membrane, where they may help functionally tether mitochondria to peroxisomes.
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收录类别	SCIE
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS类目	Biology ; Multidisciplinary Sciences
WOS记录号	WOS:000791792900004
出版者	NATURE PORTFOLIO
原始文献类型	Article
Scopus 记录号	2-s2.0-85129747345
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/243344
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_庄敏组
通讯作者	Zhuang, Min
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310007, Peoples R China; 5.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Urol, Shanghai 200080, Peoples R China; 6.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China; 7.Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Huo, Yinbo,Sun, Weiping,Shi, Tiezhu,et al. The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes[J]. COMMUNICATIONS BIOLOGY,2022,5(1):423.
APA	Huo, Yinbo,Sun, Weiping,Shi, Tiezhu,Gao, Song,&Zhuang, Min.(2022).The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes.COMMUNICATIONS BIOLOGY,5(1),423.
MLA	Huo, Yinbo,et al."The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes".COMMUNICATIONS BIOLOGY 5.1(2022):423.