Facet-Specific Assembly of Proteins on SrTiO3 Polyhedral Nanocrystals

doi:10.1038/srep05084

	Facet-Specific Assembly of Proteins on SrTiO3 Polyhedral Nanocrystals
	Dong, Lingqing 1,2; Luo, Qi 3,4; Cheng, Kui 1; Shi, Hui 3,4; Wang, Qi 3,4; Weng, Wenjian 1,5; Han, Wei-Qiang1,2
	2014-05-28
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	4
发表状态	已发表
DOI	10.1038/srep05084
摘要	Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-specific assembly of proteins, such as albumin, immunoglobulin and protamine, on {100} facets of SrTiO3 polyhedral nanocrystals, while none on {110} facets. Molecular dynamics simulations indicate the immobile surface hydration layer might play a barrier role to effectively prevent proteins adsorption on specific {110} facets. This work thus provides new insights into the fundamentally understanding of protein-nanomaterial interactions, and open a novel, general and facile route to control the selective adsorption of various proteins on various nanocrystals.
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51072178] ; National Natural Science Foundation of China[51272228] ; National Natural Science Foundation of China[81071258] ; National Natural Science Foundation of China[21273200]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000336425000004
出版者	NATURE PUBLISHING GROUP
WOS关键词	LIGAND DISTRIBUTIONS ; GOLD NANOPARTICLES ; INTERFACIAL WATER ; ADSORPTION ; SURFACE ; PARTICLE ; CONFORMATION ; DELIVERY ; DRUG
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2401
专题	物质科学与技术学院_特聘教授组_韩伟强组
通讯作者	Weng, Wenjian
作者单位	1.Zhejiang Univ, Cyrus Tang Ctr Sensor Mat & Applicat, Dept Mat Sci & Engn, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China 2.Chinese Acad Sci, Ningbo Inst Mat Technol Engn, Ningbo 315210, Zhejiang, Peoples R China 3.Zhejiang Univ, Soft Matter Res Ctr, Hangzhou 310027, Zhejiang, Peoples R China 4.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 6.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Dong, Lingqing,Luo, Qi,Cheng, Kui,et al. Facet-Specific Assembly of Proteins on SrTiO3 Polyhedral Nanocrystals[J]. SCIENTIFIC REPORTS,2014,4.
APA	Dong, Lingqing.,Luo, Qi.,Cheng, Kui.,Shi, Hui.,Wang, Qi.,...&Han, Wei-Qiang.(2014).Facet-Specific Assembly of Proteins on SrTiO3 Polyhedral Nanocrystals.SCIENTIFIC REPORTS,4.
MLA	Dong, Lingqing,et al."Facet-Specific Assembly of Proteins on SrTiO3 Polyhedral Nanocrystals".SCIENTIFIC REPORTS 4(2014).