3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network
Li, Li1; Wang, Duolin2; Xue, Mengzhu1; Mi, Xianqiang1; Liang, Yanchun2; Wang, Peng1,3
2014-06-23
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号4
发表状态已发表
DOI10.1038/srep05406
摘要Competing endogenous RNA (ceRNA) interactions form a multilayered network that regulates gene expression in various biological pathways. Recent studies have demonstrated novel roles of ceRNA interactions in tumorigenesis, but the dynamics of the ceRNA network in cancer remain unexplored. Here, we examine ceRNA network dynamics in prostate cancer from the perspective of alternative cleavage and polyadenylation (APA) and reveal the principles of such changes. Analysis of exon array data revealed that both shortened and lengthened 3'UTRs are abundant. Consensus clustering with APA data stratified cancers into groups with differing risks of biochemical relapse and revealed that a ceRNA subnetwork enriched with cancer genes was specifically dysregulated in high-risk cancers. The novel connection between 3'UTR shortening and ceRNA network dysregulation was supported by the unusually high number of microRNA response elements (MREs) shared by the dysregulated ceRNA interactions and the significantly altered 3'UTRs. The dysregulation followed a fundamental principle in that ceRNA interactions connecting genes that show opposite trends in expression change are preferentially dysregulated. This targeted dysregulation is responsible for the majority of the observed expression changes in genes with significant ceRNA dysregulation and represents a novel mechanism underlying aberrant oncogenic expression.
收录类别SCI
语种英语
资助项目Science and Technology Commission of Shanghai Municipality grant[12DZ1910800]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000337888600020
出版者NATURE PUBLISHING GROUP
WOS关键词MESSENGER-RNAS ; BREAST-CANCER ; 3' UTRS ; CELLS ; POLYADENYLATION ; MICRORNAS ; PTEN ; RECOGNITION ; WIDESPREAD ; STABILITY
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2394
专题生命科学与技术学院_特聘教授组_王鹏组
通讯作者Wang, Peng
作者单位1.Chinese Acad Sci, Shanghai Adv Res Inst, Key Lab Syst Biol, Beijing 100864, Peoples R China
2.Jilin Univ, Coll Comp Sci & Technol, Changchun, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Li, Li,Wang, Duolin,Xue, Mengzhu,et al. 3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network[J]. SCIENTIFIC REPORTS,2014,4.
APA Li, Li,Wang, Duolin,Xue, Mengzhu,Mi, Xianqiang,Liang, Yanchun,&Wang, Peng.(2014).3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network.SCIENTIFIC REPORTS,4.
MLA Li, Li,et al."3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network".SCIENTIFIC REPORTS 4(2014).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Li, Li]的文章
[Wang, Duolin]的文章
[Xue, Mengzhu]的文章
百度学术
百度学术中相似的文章
[Li, Li]的文章
[Wang, Duolin]的文章
[Xue, Mengzhu]的文章
必应学术
必应学术中相似的文章
[Li, Li]的文章
[Wang, Duolin]的文章
[Xue, Mengzhu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1038@srep05406.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。