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3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network | |
Li, Li1; Wang, Duolin2; Xue, Mengzhu1; Mi, Xianqiang1; Liang, Yanchun2; Wang, Peng1,3 | |
2014-06-23 | |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 4 |
发表状态 | 已发表 |
DOI | 10.1038/srep05406 |
摘要 | Competing endogenous RNA (ceRNA) interactions form a multilayered network that regulates gene expression in various biological pathways. Recent studies have demonstrated novel roles of ceRNA interactions in tumorigenesis, but the dynamics of the ceRNA network in cancer remain unexplored. Here, we examine ceRNA network dynamics in prostate cancer from the perspective of alternative cleavage and polyadenylation (APA) and reveal the principles of such changes. Analysis of exon array data revealed that both shortened and lengthened 3'UTRs are abundant. Consensus clustering with APA data stratified cancers into groups with differing risks of biochemical relapse and revealed that a ceRNA subnetwork enriched with cancer genes was specifically dysregulated in high-risk cancers. The novel connection between 3'UTR shortening and ceRNA network dysregulation was supported by the unusually high number of microRNA response elements (MREs) shared by the dysregulated ceRNA interactions and the significantly altered 3'UTRs. The dysregulation followed a fundamental principle in that ceRNA interactions connecting genes that show opposite trends in expression change are preferentially dysregulated. This targeted dysregulation is responsible for the majority of the observed expression changes in genes with significant ceRNA dysregulation and represents a novel mechanism underlying aberrant oncogenic expression. |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Science and Technology Commission of Shanghai Municipality grant[12DZ1910800] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000337888600020 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | MESSENGER-RNAS ; BREAST-CANCER ; 3' UTRS ; CELLS ; POLYADENYLATION ; MICRORNAS ; PTEN ; RECOGNITION ; WIDESPREAD ; STABILITY |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2394 |
专题 | 生命科学与技术学院_特聘教授组_王鹏组 |
通讯作者 | Wang, Peng |
作者单位 | 1.Chinese Acad Sci, Shanghai Adv Res Inst, Key Lab Syst Biol, Beijing 100864, Peoples R China 2.Jilin Univ, Coll Comp Sci & Technol, Changchun, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Li, Li,Wang, Duolin,Xue, Mengzhu,et al. 3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network[J]. SCIENTIFIC REPORTS,2014,4. |
APA | Li, Li,Wang, Duolin,Xue, Mengzhu,Mi, Xianqiang,Liang, Yanchun,&Wang, Peng.(2014).3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network.SCIENTIFIC REPORTS,4. |
MLA | Li, Li,et al."3 ' UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network".SCIENTIFIC REPORTS 4(2014). |
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