Emerging roles and functional mechanisms of PIWI-interacting RNAs

doi:10.1038/s41580-022-00528-0

	Emerging roles and functional mechanisms of PIWI-interacting RNAs
	Wang, Xin 1,2; Ramat, Anne 3; Simonelig, Martine 3; Liu, Mo-Fang1,2,4
	2022-09
发表期刊	NATURE REVIEWS MOLECULAR CELL BIOLOGY (IF:81.3[JCR-2023],115.5[5-Year])
ISSN	1471-0072
EISSN	1471-0080
发表状态	已发表
DOI	10.1038/s41580-022-00528-0
摘要	["PIWI-interacting RNAs (piRNAs) are small non-coding RNAs with essential roles in germ line development through silencing of transposable elements and in regulation of protein-coding genes. Recent studies have deepened our understanding of the biogenesis and function of piRNAs and their roles in infertility, cancer and neurological diseases in humans.","PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells, piRNAs have essential roles in germ line development. The first function of PIWI-piRNA complexes to be described was the silencing of transposable elements, which is crucial for maintaining the integrity of the germ line genome. Later studies provided new insights into the functions of PIWI-piRNA complexes by demonstrating that they regulate protein-coding genes. Recent studies of piRNA biology, including in new model organisms such as golden hamsters, have deepened our understanding of both piRNA biogenesis and piRNA function. In this Review, we discuss the most recent advances in our understanding of piRNA biogenesis, the molecular mechanisms of piRNA function and the emerging roles of piRNAs in germ line development mainly in flies and mice, and in infertility, cancer and neurological diseases in humans."]
URL	查看原文
收录类别	SCI ; SCIE ; SCOPUS
语种	英语
资助项目	National Key R&D Program of China["2021YFC2700200","2017YFA0504400"] ; National Natural Science Foundation of China["91940305","31830109","31821004","31961133022","91640201","32101037"] ; Chinese Academy of Sciences[XDB19010203] ; Science and Technology Commission of Shanghai Municipality["2017SHZDZX01","19JC1410200","21YF1452700","21ZR1470500","17JC1420100"] ; Innovative Research Team of High-Level Local Universities in Shanghai[SHSMU-ZDCX20210902] ; Young Elite Scientist Sponsorship Program of the China Association for Science and Technology[2021QNRC001] ; French Agence Nationale de la Recherche["ANR-17-CE12-0011-01","ANR-19-CE12-0031","ANR-21-CE12-0035-01"] ; CNRS-University of Montpellier[UMR9002]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000854713700002
出版者	NATURE PORTFOLIO
Scopus 记录号	2-s2.0-85138116052
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/231969
专题	生命科学与技术学院_特聘教授组_刘默芳组
通讯作者	Simonelig, Martine; Liu, Mo-Fang
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Ctr Excellence Mol Cell Sci,Shanghai Inst Biochem, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou Inst ForAdv Study, Sch Life Sci, Hangzhou, Peoples R China 3.Univ Montpellier, CNRS, Inst Human Genet, Montpellier, France 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Xin,Ramat, Anne,Simonelig, Martine,et al. Emerging roles and functional mechanisms of PIWI-interacting RNAs[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY,2022.
APA	Wang, Xin,Ramat, Anne,Simonelig, Martine,&Liu, Mo-Fang.(2022).Emerging roles and functional mechanisms of PIWI-interacting RNAs.NATURE REVIEWS MOLECULAR CELL BIOLOGY.
MLA	Wang, Xin,et al."Emerging roles and functional mechanisms of PIWI-interacting RNAs".NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022).