IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

doi:10.1186/s13008-018-0038-0

	IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
	Keppeke, Gerson Dierley 1; Chang, Chia Chun 1,2; Peng, Min 2; Chen, Li-Yu 1; Lin, Wei-Cheng 3; Pai, Li-Mei 3,4,5; Andrade, Luis Eduardo Coelho 6; Sung, Li-Ying 2,7; Liu, Ji-Long1,8
	2018-06-15
发表期刊	CELL DIVISION
ISSN	1747-1028
卷号	13
发表状态	已发表
DOI	10.1186/s13008-018-0038-0
摘要	Background: Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a variety of conditions. However, the regulation and function of the cytoophidium are still elusive.
关键词	Cytoophidium IMPDH enzyme GTP biosynthesis IMP Cell proliferation
收录类别	SCI ; SCIE
资助项目	Ministry of Science and Technology, Taiwan, ROC[104-2313-B-002-035-MY3] ; Ministry of Science and Technology, Taiwan, ROC[106-2917-I-002-043]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000435577400001
出版者	BMC
WOS关键词	INOSINE MONOPHOSPHATE DEHYDROGENASE ; CTP SYNTHASE ; 5'-MONOPHOSPHATE DEHYDROGENASE ; RETINITIS-PIGMENTOSA ; ROD/RING STRUCTURES ; INHIBITORS ; GENE ; COMPARTMENTATION ; PURIFICATION ; METABOLISM
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/23055
专题	生命科学与技术学院生命科学与技术学院_PI研究组_刘冀珑组
共同第一作者	Chang, Chia Chun
通讯作者	Sung, Li-Ying; Liu, Ji-Long
作者单位	1.Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England 2.Natl Taiwan Univ, Inst Biotechnol, Taipei 106, Taiwan 3.Chang Gung Univ, Coll Med, Mol Med Res Ctr, Taoyuan 333, Taiwan 4.Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Taoyuan 333, Taiwan 5.Chang Gung Univ, Coll Med, Dept Biochem, Taoyuan 333, Taiwan 6.Univ Fed Sao Paulo, Escola Paulista Med, Rheumatol Div, BR-04023062 Sao Paulo, SP, Brazil 7.Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Keppeke, Gerson Dierley,Chang, Chia Chun,Peng, Min,et al. IMP/GTP balance modulates cytoophidium assembly and IMPDH activity[J]. CELL DIVISION,2018,13.
APA	Keppeke, Gerson Dierley.,Chang, Chia Chun.,Peng, Min.,Chen, Li-Yu.,Lin, Wei-Cheng.,...&Liu, Ji-Long.(2018).IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.CELL DIVISION,13.
MLA	Keppeke, Gerson Dierley,et al."IMP/GTP balance modulates cytoophidium assembly and IMPDH activity".CELL DIVISION 13(2018).