上海科技大学知识管理系统

Nanoparticle play an important role in drug delivery system. Traditional drug delivery methods have too many hinders that can overcome by embellishing nanopaticle. For those advantage, nanoparticle application in drug delivery system as research interest in great demand. This paper overview gold nanoparticle used as in protein nanocarriers and used in nucleic acid delivery. Meanwhile use less length to introduce the mesoporous nanoparticle in drug delivery to offer another think about nanoparticle using in drug delivery. Protein expression disorder or dysfunctional protein production leads to disease state. Restoring biological function by supplementing protein is the safest, most direct and most effective way to treat diseases, but their therapeutic use is limited because they are vulnerable to endosomal internalization, instability and immunogenicity. Efficient and universal system based on gold nanoparticle DNA has characteristics similar to nanoblocks, allowing any recombinant protein to be loaded and transported to mammalian living systems without additional modification. And as report, nucleic acid can treat some genetic disease and cancer, gold nanoparticle can be a good tool to delivery nucleic acid. In addition, mesoporous nanoparticle also can help some drug delivery system to control their release. © 2022 SPIE. Downloading of the abstract is permitted for personal use only.