Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment

doi:10.1007/s11033-014-3775-4

	Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment
	Wu, Xuming 1; Chen, Peizhan 2,3; Ou, Yiyi 4; Liu, Jibin 1; Li, Chenglin2,3 ; Wang, Hui2,3,5 ; Qiang, Fulin 1
	2015-02
发表期刊	MOLECULAR BIOLOGY REPORTS (IF:2.6[JCR-2023],2.6[5-Year])
ISSN	0301-4851
卷号	42 期号:2 页码:355-361
发表状态	已发表
DOI	10.1007/s11033-014-3775-4
摘要	Adiponectin is a protein hormone secreted exclusively by adipocytes and it is responsible for insulin sensitization in the human body. Deregulation of adiponectin and its downstream signaling pathway genes have been found to be involved in the gastric cancer carcinogenesis; however, whether the variants on adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) affect the prognosis of gastric cancer patients are still unknown. Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients. No significant association between the four variants and the overall survival of the gastric cancer patients was found. However, for those patients without a previous history of alcohol drinking, the rs266729 GG/CG genotype carriers showed a significantly decreased gastric cancer mortality compared to homogeneity CC patients (HR 0.74, 95 % CI 0.56-0.97; p = 0.032) after adjustment for variants age, sex, smoking status, tumor stage, tumor location and post-surgery chemotherapy. No significant association between the variant rs266729 genotypes and overall survival for the gastric cancer patients with an alcohol drinking habit. These data suggested that the variant rs266729 was an independent prognostic factor for the never drinking gastric cancer patients who received surgical treatment.
关键词	Adiponectin Adiponectin receptor 1 Gastric cancer Overall survival
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[2012KIP308] ; Chinese Academy of Sciences[2012KIP515]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000349006900005
出版者	SPRINGER
WOS关键词	SERUM ADIPONECTIN CONCENTRATIONS ; PLASMA ADIPONECTIN ; PROSTATE-CANCER ; BREAST-CANCER ; ALCOHOL-CONSUMPTION ; ENDOMETRIAL CANCER ; CIRCULATING ADIPONECTIN ; CELL-PROLIFERATION ; COLORECTAL-CANCER ; GENETIC-VARIANTS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2264
专题	生命科学与技术学院_特聘教授组_王慧组信息科学与技术学院_硕士生
通讯作者	Qiang, Fulin
作者单位	1.Nantong Tumor Hosp, Nantong 226000, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res, Inst Nutr Sci, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Gen Hosp Navy, Dept Med, Beijing 100037, Peoples R China 5.China Natl Ctr Food Safety Risk Assessment, Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xuming,Chen, Peizhan,Ou, Yiyi,et al. Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment[J]. MOLECULAR BIOLOGY REPORTS,2015,42(2):355-361.
APA	Wu, Xuming.,Chen, Peizhan.,Ou, Yiyi.,Liu, Jibin.,Li, Chenglin.,...&Qiang, Fulin.(2015).Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment.MOLECULAR BIOLOGY REPORTS,42(2),355-361.
MLA	Wu, Xuming,et al."Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment".MOLECULAR BIOLOGY REPORTS 42.2(2015):355-361.