Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene

doi:10.1016/j.taap.2015.01.006

	Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene
	Ba, Qian 1,2; Li, Junyang 1; Huang, Chao 1; Li, Jingquan 1,2; Chu, Ruiai 1,2; Wu, Yongning 2; Wang, Hui1,2,3
	2015-03
发表期刊	TOXICOLOGY AND APPLIED PHARMACOLOGY (IF:3.3[JCR-2023],3.6[5-Year])
ISSN	0041-008X
卷号	283 期号:2 页码:83-91
发表状态	已发表
DOI	10.1016/j.taap.2015.01.006
摘要	Benzo(a)pyrene is a Common environmental and foodborne pollutant that has been identified as a human carcinogen. Although the carcinogenicity of benzo(a)pyrene has been extensively reported, its precise molecular mechanisms and the influence on system-level protein networks are not well understood. To investigate the system-level influence of benzo(a)pyrene on protein interactions and regulatory networks, a benzo(a)pyrene-rewired protein interaction network was constructed based on 769 key proteins derived from more than 500 literature reports. The protein interaction network rewired by benzo(a)pyrene was a scale-free, highly-connected biological system. Ten modules were identified, and 25 signaling pathways were enriched, most of which belong to the human diseases category, especially cancer and infectious disease. In addition, two lung-specific and two liver-specific pathways were identified. Three pathways were specific in short and medium-term networks (<48 h), and five pathways were enriched only in the medium-term network (6 h-48 h). Finally, the expression of linker genes in the network was validated by Western blotting. These findings establish the overall, tissue- and time-specific benzo(a)pyrene-rewired protein interaction networks and provide insights into the biological effects and molecular mechanisms of action of benzo(a)pyrene. (C) 2015 Elsevier Inc. All rights reserved.
关键词	Benzo(a)pyrene Protein network Module Signaling pathway
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[12431900500] ; Science and Technology Commission of Shanghai Municipality[14391901800]
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000350008300002
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; CARCINOGENESIS
原始文献类型	Article
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2257
专题	生命科学与技术学院_特聘教授组_王慧组
通讯作者	Wu, Yongning
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China 2.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Ba, Qian,Li, Junyang,Huang, Chao,et al. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2015,283(2):83-91.
APA	Ba, Qian.,Li, Junyang.,Huang, Chao.,Li, Jingquan.,Chu, Ruiai.,...&Wang, Hui.(2015).Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene.TOXICOLOGY AND APPLIED PHARMACOLOGY,283(2),83-91.
MLA	Ba, Qian,et al."Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene".TOXICOLOGY AND APPLIED PHARMACOLOGY 283.2(2015):83-91.