FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation
Wang, Feng1,2; Cai, Bing1,2; Li, Kai-Cheng1,2; Hu, Xu-Ye4; Lu, Ying-Jin1,2; Wang, Qiong3; Bao, Lan3,5; Zhang, Xu1,2,5
2015-03
Source PublicationCELL RESEARCH
ISSN1001-0602
Volume25Issue:3Pages:318-334
Status已发表
DOI10.1038/cr.2015.12
AbstractNa+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons. Nociceptive afferent neurons express not only the alpha and beta subunits of NKA but also the gamma subunit FXYD2. However, the neural function of FXYD2 is unknown. The present study shows that FXYD2 in nociceptive neurons is necessary for maintaining the mechanical allodynia induced by peripheral inflammation. FXYD2 interacted with a1NKA and negatively regulated the NKA activity, depolarizing the membrane potential of nociceptive neurons. Mechanical allodynia initiated in FXYD2-deficient mice was abolished 4 days after inflammation, whereas it persisted for at least 3 weeks in wild-type mice. Importantly, the FXYD2/alpha 1NKA interaction gradually increased after inflammation and peaked on day 4 post inflammation, resulting in reduction of NKA activity, depolarization of neuron membrane and facilitation of excitatory afferent neurotransmission. Thus, the increased FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation.
KeywordFXYD2 Na+,K+-ATPase inflammatory pain dorsal root ganglion
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program (B) of Chinese Academy of Sciences[XDB01020300]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000350568800008
PublisherINST BIOCHEMISTRY & CELL BIOLOGY
WOS KeywordFOLLISTATIN-LIKE 1 ; AFFERENT NEURONS ; OPIOID RECEPTORS ; BETA-SUBUNIT ; NA+/K+ PUMP ; K+-ATPASE ; NA,K-ATPASE ; PAIN ; INHIBITION ; TRANSPORT
Original Document TypeArticle
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2254
Collection生命科学与技术学院_特聘教授组_鲍岚组
生命科学与技术学院_特聘教授组_张旭组
Corresponding AuthorZhang, Xu
Affiliation1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, XuHui Cent Hosp, Shanghai Clin Ctr, Shanghai 200031, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
Corresponding Author AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Wang, Feng,Cai, Bing,Li, Kai-Cheng,et al. FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation[J]. CELL RESEARCH,2015,25(3):318-334.
APA Wang, Feng.,Cai, Bing.,Li, Kai-Cheng.,Hu, Xu-Ye.,Lu, Ying-Jin.,...&Zhang, Xu.(2015).FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation.CELL RESEARCH,25(3),318-334.
MLA Wang, Feng,et al."FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation".CELL RESEARCH 25.3(2015):318-334.
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