FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation

doi:10.1038/cr.2015.12

	FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation
	Wang, Feng 1,2; Cai, Bing 1,2; Li, Kai-Cheng 1,2; Hu, Xu-Ye 4; Lu, Ying-Jin 1,2; Wang, Qiong 3; Bao, Lan3,5 ; Zhang, Xu1,2,5
	2015-03
发表期刊	CELL RESEARCH (IF:28.1[JCR-2023],36.4[5-Year])
ISSN	1001-0602
卷号	25 期号:3 页码:318-334
发表状态	已发表
DOI	10.1038/cr.2015.12
摘要	Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons. Nociceptive afferent neurons express not only the alpha and beta subunits of NKA but also the gamma subunit FXYD2. However, the neural function of FXYD2 is unknown. The present study shows that FXYD2 in nociceptive neurons is necessary for maintaining the mechanical allodynia induced by peripheral inflammation. FXYD2 interacted with a1NKA and negatively regulated the NKA activity, depolarizing the membrane potential of nociceptive neurons. Mechanical allodynia initiated in FXYD2-deficient mice was abolished 4 days after inflammation, whereas it persisted for at least 3 weeks in wild-type mice. Importantly, the FXYD2/alpha 1NKA interaction gradually increased after inflammation and peaked on day 4 post inflammation, resulting in reduction of NKA activity, depolarization of neuron membrane and facilitation of excitatory afferent neurotransmission. Thus, the increased FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation.
关键词	FXYD2 Na+,K+-ATPase inflammatory pain dorsal root ganglion
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program (B) of Chinese Academy of Sciences[XDB01020300]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000350568800008
出版者	INST BIOCHEMISTRY & CELL BIOLOGY
WOS关键词	FOLLISTATIN-LIKE 1 ; AFFERENT NEURONS ; OPIOID RECEPTORS ; BETA-SUBUNIT ; NA+/K+ PUMP ; K+-ATPASE ; NA,K-ATPASE ; PAIN ; INHIBITION ; TRANSPORT
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2254
专题	生命科学与技术学院_特聘教授组_鲍岚组生命科学与技术学院_特聘教授组_张旭组
通讯作者	Zhang, Xu
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, XuHui Cent Hosp, Shanghai Clin Ctr, Shanghai 200031, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Feng,Cai, Bing,Li, Kai-Cheng,et al. FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation[J]. CELL RESEARCH,2015,25(3):318-334.
APA	Wang, Feng.,Cai, Bing.,Li, Kai-Cheng.,Hu, Xu-Ye.,Lu, Ying-Jin.,...&Zhang, Xu.(2015).FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation.CELL RESEARCH,25(3),318-334.
MLA	Wang, Feng,et al."FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation".CELL RESEARCH 25.3(2015):318-334.