Quantitating and Dating Recent Gene Flow between European and East Asian Populations

doi:10.1038/srep09500

	Quantitating and Dating Recent Gene Flow between European and East Asian Populations
	Qin, Pengfei 1; Zhou, Ying 1; Lou, Haiyi 1; Lu, Dongsheng 1; Yang, Xiong 1; Wang, Yuchen 1; Jin, Li 2,3; Chung, Yeun-Jun 4; Xu, Shuhua1,5,6
	2015-04-02
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5
发表状态	已发表
DOI	10.1038/srep09500
摘要	Historical records indicate that extensive cultural, commercial and technological interaction occurred between European and Asian populations. What have been the biological consequences of these contacts in terms of gene flow? We systematically estimated gene flow between Eurasian groups using genome-wide polymorphisms from 34 populations representing Europeans, East Asians, and Central/South Asians. We identified recent gene flow between Europeans and Asians in most populations we studied, including East Asians and Northwestern Europeans, which are normally considered to be non-admixed populations. In addition we quantitatively estimated the extent of this gene flow using two statistical approaches, and dated admixture events based on admixture linkage disequilibrium. Our results indicate that most genetic admixtures occurred between 2,400 and 310 years ago and show the admixture proportions to be highly correlated with geographic locations, with the highest admixture proportions observed in Central Asia and the lowest in East Asia and Northwestern Europe. Interestingly, we observed a North-to-South decline of European gene flow in East Asians, suggesting a northern path of European gene flow diffusing into East Asian populations. Our findings contribute to an improved understanding of the history of human migration and the evolutionary mechanisms that have shaped the genetic structure of populations in Eurasia.
收录类别	SCI
语种	英语
资助项目	National Science Foundation of China (NSFC)[91331204] ; National Science Foundation of China (NSFC)[31171218]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000352099000001
出版者	NATURE PUBLISHING GROUP
WOS关键词	GENOME VARIATION ; SILK ROAD ; ADMIXTURE ; HISTORY ; INFERENCE ; ASSOCIATION ; JACKKNIFE ; MAP
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2231
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Fudan Univ, Minist Educ, MOE Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China 3.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China 4.Catholic Univ, Coll Med, Dept Microbiol, Integrated Res Ctr Genome Polymorphism, Seoul 137701, South Korea 5.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 6.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Qin, Pengfei,Zhou, Ying,Lou, Haiyi,et al. Quantitating and Dating Recent Gene Flow between European and East Asian Populations[J]. SCIENTIFIC REPORTS,2015,5.
APA	Qin, Pengfei.,Zhou, Ying.,Lou, Haiyi.,Lu, Dongsheng.,Yang, Xiong.,...&Xu, Shuhua.(2015).Quantitating and Dating Recent Gene Flow between European and East Asian Populations.SCIENTIFIC REPORTS,5.
MLA	Qin, Pengfei,et al."Quantitating and Dating Recent Gene Flow between European and East Asian Populations".SCIENTIFIC REPORTS 5(2015).